2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-177567
    Cephalosporin C analog-1 30361-42-3
    Cephalosporin C analog-1 is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin.
    Cephalosporin C analog-1
  • HY-177708
    N-Acetyltryptamine α-D-Glucose-3-phosphate 2914912-82-4
    N-Acetyltryptamine α-D-Glucose-3-phosphate (Compound 30) a nucleotide analogue. N-Acetyltryptamine α-D-Glucose-3-phosphate can modify RNA and enhance its stability.by covalently connecting modular glucose nucleotides. N-Acetyltryptamine α-D-Glucose-3-phosphate can be used for the researches of cancer and infection.
    N-Acetyltryptamine α-D-Glucose-3-phosphate
  • HY-177775
    pro-N6pA 3004761-03-6
    pro-N6pA is a cell-permeable pronucleotide probe. Pro-N6pA can be used to track AMPylated proteins. Pro-N6pA can also be used in bacterial infection research.
    pro-N6pA
  • HY-177791
    vRNPs degrader-1
    vRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research.
    vRNPs degrader-1
  • HY-177817
    CL9 sodium 98%
    CL9 sodium, a RIG-I-specific RNA aptamer, activates signaling pathways for IFNβ produciton and efficiently blocks viral replication. RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β prod
    CL9 sodium
  • HY-177889
    Sal-AMP 863238-52-2
    Sal-AMP is an acyl-adenylate intermediate. Sal-AMP can be loaded by MbtA on to the thiolation domain of MbtB. Sal-AMP can be used in tuberculosis research.
    Sal-AMP
  • HY-177910
    Anticoronavirus agent-1 75445-60-2
    Anticoronavirus agent-1 (Compound IV-2) is a 1,4-naphthone compound and is a 3CL hydrolase inhibitor (3C-like proteinase) of the 19-nCoV novel coronavirus. Anticoronavirus agent-1 has low cytotoxity on HSF cells. Anticoronavirus agent-1 can be used for the study of the novel coronavirus.
    Anticoronavirus agent-1
  • HY-177949
    ETX1317 2209871-79-2
    ETX1317 is a β-lactamase inhibitor that restores the antibacterial activity of several classes of β-lactam antibiotics, including third-generation cephalosporins such as Cefpodoxime (HY-A0251). ETX1317 can be used for research on bacterial infection.
    ETX1317
  • HY-177978
    LysoPE(P-16:0/0:0) 174062-72-7
    LysoPE(P-16:0/0:0) is a lysophosphatidylethanolamine and metabolite. LysoPE(P-16:0/0:0) is significantly decreased in the plasma of spinal tuberculosis. LysoPE(P-16:0/0:0) can be screened as potential diagnostic biomarkers for spinal tuberculosis.
    LysoPE(P-16:0/0:0)
  • HY-177996
    Clindamycin palmitate 36688-78-5 98%
    Clindamycin palmitate is an antibacterial agent. Clindamycin palmitate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin.
    Clindamycin palmitate
  • HY-178019
    NDM-1-IN-10 3044733-61-8
    NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 36  nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli ( MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1). NDM-1-IN-10 can be used for bacterial infections research.
    NDM-1-IN-10
  • HY-178027
    SARS-CoV-2 nsp14-IN-6
    SARS-CoV-2 nsp14-IN-6 (Compound 35) is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC50 of 0.24  μM. SARS-CoV-2 nsp14-IN-6 has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 can be used for human coronaviruses research.
    SARS-CoV-2 nsp14-IN-6
  • HY-178031
    HIV-1-IN-87 98%
    HIV-1-IN-87 (Compound 11x) is a dual-site HIV-1 inhibitor targeting the non-nucleoside reverse transcriptase inhibitor binding pocket (NNIBP) and its adjacent site (NNIAS). HIV-1-IN-87 has potent antiviral activities against wild-type and mutant strains (such as L100I, K103N and Y181C) (EC50: 4.1-150 nM). HIV-1-IN-87 can be used for HIV-1 infections like acquired immune deficiency syndrome (AIDS) research.
    HIV-1-IN-87
  • HY-178033
    Antileishmanial agent-35 100611-91-4
    Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC50 of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research.
    Antileishmanial agent-35
  • HY-178040
    Insecticidal agent 26
    Insecticidal agent 26 (Compound A11), a spiro insecticidal agent, is a dual-functional inhibitor of pest Acetyl-CoA carboxylase (ACC) and Pyruvate carboxylase (PC). Insecticidal agent 26 has potent insecticidal activity against Sogatella furcifera with a LC50 of 11.0  μg/mL, with significant biosafety to bees. Insecticidal agent 26 can be used for management of white-backed planthoppers (WBPs).
    Insecticidal agent 26
  • HY-178050
    SDH-IN-30 98%
    SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research.
    SDH-IN-30
  • HY-178051
    Antifungal agent 135 98%
    Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC50 s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against Phytophthora capsici and Valsa mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth.
    Antifungal agent 135
  • HY-178056
    Carbonic anhydrase-IN-2
    Carbonic anhydrase-IN-2 is an orally active carbonic anhydrase inhibitor. Carbonic anhydrase-IN-2 shows antibacterial effect against various vancomycin-resistant Enterococcus (VRE) strains. Carbonic anhydrase-IN-2 can be used for the research of infection, such as E. faecium.
    Carbonic anhydrase-IN-2
  • HY-178064
    Antiparasitic agent-29
    Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC50 of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research.
    Antiparasitic agent-29
  • HY-178101
    WRS22
    WRS22, a derivative of Tirabrutinib (HY-15771), is a bacterial Tryptophanyl-tRNA synthetase (TrpRS) inhibitor with a Kd of 0.33 μM for EcTrpRS. WRS22 can be used for antibiotic resistance research.
    WRS22
Cat. No. Product Name / Synonyms Application Reactivity