Carbonic anhydrase-IN-2
Carbonic anhydrase-IN-2 is an orally active carbonic anhydrase inhibitor. Carbonic anhydrase-IN-2 shows antibacterial effect against various vancomycin-resistant Enterococcus (VRE) strains. Carbonic anhydrase-IN-2 can be used for the research of infection, such as E. faecium.
For research use only. We do not sell to patients.
- Formula: C12H14N4O3S2
- Molecular Weight:326.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Carbonic anhydrase-IN-2 (Compound 20) (184-3060 nM, 18-20 h) inhibits proliferation of various vancomycin-resistant Enterococcus (VRE) strains including E. faecium NR-31909 and E. faecalis NR-31971, with an MIC50 of 184 nM and an MIC90 of 3060 nM[1].
Carbonic anhydrase-IN-2 potently inhibits E. faecium α-carbonic anhydrase (Efα-CA) (Ki = 31.6 nM) and γ-carbonic anhydrase (Efγ-CA) (Ki = 62.3 nM)[1].
Carbonic anhydrase-IN-2 (24 h) shows bacteriostatic effect against E. faecium NR-31909[1].
Carbonic anhydrase-IN-2 (18-20 h) shows no inhibitory activity against 12 gut commensal strains including Lactobacillus, Bacteroides and Bifidobacterium with MIC >784 μM[1].
Carbonic anhydrase-IN-2 (0-128 μg/mL, 24 h) shows no obvious cytotoxicity in Vero cells, maintaining cell viability at 95-100%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells
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Concentration:0, 4, 8, 16, 32, 64 nd 128 μg/mL
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Incubation Time:24 h
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Result:Maintained cell viability at 95-100%.
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUClast | MRT | Vz | CL |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | p.o. | 4.64 h | 0.167 h | 16.9 μM | 12.48 μM·h | 3.74 h | 31.18 L/kg | 77.62 mL/min/kg |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:E. faecium NR-31909 septicemic peritonitis[1]
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Dosage:20 mg/kg
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Administration:Orally administration, daily for 3 days, starting 1 h post-infection
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Result:Reduced NR-31909 burden by 96.8% in kidney, 98.7% in liver, and 96.8% in spleen.
Chemical Information
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Molecular Weight 326.39
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Formula C12H14N4O3S2
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SMILES
O=S(C1=NN=C(S1)NC(CCC2=CC=C(C=C2)C)=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbonic anhydrase-IN-2 Related Classifications
HY-178056 Related Classifications
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