2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W590539
    ω-azido-C6 Ceramide 2108102-18-5 98%
    ω-azido-C6 Ceramide reduces the membrane potential, and exhibits antibacterial activity against Neisseria, with MIC of 2 µg/ml for N. meningitidis MC58 and N. gonorrhoeae FA1090.
    ω-azido-C6 Ceramide
  • HY-W614623
    (S)-ML188 1417700-12-9 98%
    (S)-ML188 is a SARS-CoV 3-chymotrypsin-like protease (3CLpro) inhibitor (IC50: 1.5 μM). (S)-ML188 has antiviral activity with an EC50 value of 12.9 μM against SARS-CoV. (S)-ML188 inhibits the activity of 3CLpro via non-covalent binding and can be used in the study of SARS-CoV.
    (S)-ML188
  • HY-W631668
    Antileishmanial agent-34 139276-16-7 98%
    Antileishmanial agent-34 (Fig. (9), compound 3) is an aurone with antileishmanial activity. Antileishmanial agent-34 against extracellular forms of Lmaj, Ldon, Linf and Lenr as well as against intracellular forms of Ldon (IC50 of <2 µg/mL).
    Antileishmanial agent-34
  • HY-W643167
    1,2,3-Tritridecanoylglycerol 26536-12-9 99.97%
    1,2,3-Tritridecanoyl glycerol is a synthetic triacylglycerol that contains tridecanoic acid in the sn-1, sn-2, and sn-3 positions. It has been used as a standard for the relative quantification of triacylglycerols in C. elegans fat stores. It has also been used as an internal standard for the quantification of triacylglycerols in the serum and liver of adult rat offspring receiving dietary conjugated linoleic acids during and after gestation.
    1,2,3-Tritridecanoylglycerol
  • HY-W653770
    Desmycosin 11032-98-7 98%
    Desmycosin is a macrolide antibiotic. Desmycosin exhibits biological activity against H. influenzae, S.aureus, S. pneumoniae, and S. pyogenes with MIC values of 4, 1, <0.125, and <0.125 µg/ml, respectively. Desmycosin is an acidic degradation product of tylosin.
    Desmycosin
  • HY-W653875
    Azithromycin-d5 98%
    Azithromycin-d5 (CP-62993-d5) is the deuterium labeled Azithromycin (CP-62993) (HY-17506). Azithromycin is a macrolide antibiotic useful for thestudy of a number of bacterial infections.
    Azithromycin-d5
  • HY-W653896
    Alternariol-d2 2469262-26-6 98%
    Alternariol-d2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.
    Alternariol-d2
  • HY-W653970
    5-Azacytidine-15N4 2139283-40-0 98%
    5-Azacytidine-15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
    5-Azacytidine-15N4
  • HY-W654130
    Daunorubicin-13C,d3 98%
    Daunorubicin-13C,d3 is 13C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
    Daunorubicin-13C,d3
  • HY-W654156
    Diclazuril-13C3,15N2 98%
    Diclazuril-13C3,15N2 is 13C and 15N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
    Diclazuril-13C3,15N2
  • HY-W654221
    Hydroxychloroquine O-sulfate sodium 2740402-74-6 98%
    Hydroxychloroquine O-Sulfate (HCQ O-Sulfate) sodium is a derivative of the antimalarial agent Hydroxychloroquine (HY-W031727).
    Hydroxychloroquine O-sulfate sodium
  • HY-W654567
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride 41591-87-1 98%
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride is a cationic surfactant of the silylated quaternary ammonium salt type, possessing dual functions of antibacterial activity and silane coupling. N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride can be used as a cationic silane coupling agent, antibacterial surface treatment agent, and disinfectant.
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride
  • HY-W673589
    Hexacosane, 2-Methyl- 1561-02-0 98%
    2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.
    Hexacosane, 2-Methyl-
  • HY-W673672
    4-Oxodecanoic acid 4144-54-1 98%
    4-Oxodecanoic acid (4-Ketocapric acid) is a Sex pheromone component. 4-Oxodecanoic acid can be isolated from the sternal glands on the sixth abdominal segment of unmated female Vespa velutina. When mixed with 4-oxooctanoic acid at the natural secretion ratio of 0.78 in female wasps, 4-Oxodecanoic acid exhibits an attractive effect on male Vespa velutina. 4-Oxodecanoic acid can be used in population monitoring and control research on the invasive species Vespa velutina.
    4-Oxodecanoic acid
  • HY-W677714
    SDH-IN-43 163105-64-4 98%
    SDH-IN-43 (Compound i-19) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-43 shows potent inhibitory activity against caenorhabditis elegans wirh an IC50 of 6.67 μM. SDH-IN-43 can significantly reduce caenorhabditis elegans reproductive ability and movement ability, and is also effective against drug-resistant strains of Levamisole (HY-A0106), Benzimidazole (HY-Y1825), and Ivermectin (HY-15310). SDH-IN-43 can be used for the research of parasite infection.
    SDH-IN-43
  • HY-W683885
    Dimabefylline 1703-48-6 98%
    Dimabefylline is an antimicrobial compound.
    Dimabefylline
  • HY-W686760
    (Rac)-Bromamphenicol 16803-75-1 98%
    (Rac)-Bromamphenicol is the racemate of Bromamphenicol (HY-W686760). Bromamphenicol (Compound Ib) is a derivative of Chloramphenicol (HY-B0239), and exhibits antibacterial activity. Bromamphenicol binds to S50 ribosomal subunit, interfers with the activity of peptidyl transferase, and exhibits inhibitory activity against protein synthesis.
    (Rac)-Bromamphenicol
  • HY-W698254
    Fluopsin F 31323-26-9 98%
    Fluopsin F is an antibiotic containing metallic iron with strong anti-Gram-positive and negative bacteria activity and anti-tumor activity.
    Fluopsin F
  • HY-W700069
    Gatifloxacin-d4 1190043-25-4 98%
    Gatifloxacin-d4 (AM-1155-d4) is the deuterium labeled Gatifloxacin (HY-10581). Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50 = 13.8 μg/mL for S. aureus topoisomerase IV) and E.coli DNA gyrase (IC50 = 0.109 μg/mL). Gatifloxacin can be used for the study of bacterial conjunctivitis in vivo.
    Gatifloxacin-d4
  • HY-W700241
    Norharman-d7 1216503-21-7 98%
    Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
    Norharman-d7
Cat. No. Product Name / Synonyms Application Reactivity