2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150738A
    Biotin-labeled ODN 2088 sodium
    Biotin-labeled ODN 2088 (sodium) is a potent TLR3, TLR7 and TLR9 inhibitor. Biotin-labeled ODN 2088 (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.
    Biotin-labeled ODN 2088 sodium
  • HY-150738B
    FITC-labeled ODN 2088 sodium
    FITC-labeled ODN 2088 (sodium) is a potent TLR3, TLR7 and TLR9 inhibitor. FITC-labeled ODN 2088 (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
    FITC-labeled ODN 2088 sodium
  • HY-150751A
    Biotin-labeled ODN TTAGGG sodium
    Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.
    Biotin-labeled ODN TTAGGG sodium
  • HY-150751B
    FITC-labeled ODN TTAGGG sodium
    FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
    FITC-labeled ODN TTAGGG sodium
  • HY-151216S
    rel-Paroxetine-d4 hydrochloride 1217683-35-6 98%
    rel-Paroxetine-d4 (rel-BRL29060-d4) hydrochloride is an isotope-labeled rel-Paroxetine hydrochloride.
    rel-Paroxetine-d4 hydrochloride
  • HY-15122AR
    Sinomenine hydrochloride (Standard) 6080-33-7 98%
    Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.
    Sinomenine hydrochloride (Standard)
  • HY-151611A
    UAMC-00050 free base 934622-26-1
    UAMC-00050 free base is a potent trypsin-like serine protease inhibitor. UAMC-00050 free base can be used in research of dry eye syndrome and ocular inflammation.
    UAMC-00050 free base
  • HY-153192C
    (rac)-Nerandomilast 1423719-27-0
    (rac)-Nerandomilast ((rac)-BI 1015550) is a mixture of enantiomeric isomers of Nerandomilast (HY-153192), among which only the (R)-enantiomer (i.e., Nerandomilast) has PDE4B inhibitory activity; the (S)-enantiomer (i.e., (S)-Nerandomilast (HY-153192B)) is basically inactive.
    (rac)-Nerandomilast
  • HY-15321S1
    Etoricoxib-13C,d3 2748267-73-2 98%
    Etoricoxib-13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
    Etoricoxib-13C,d3
  • HY-153321A
    (R,R)-Bexobrutideg 2649400-33-7 98.83%
    (R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker).
    (R,R)-Bexobrutideg
  • HY-153479A
    Aganirsen sodium
    Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).
    Aganirsen sodium
  • HY-153479C
    Aganirsen sodium scrambled negative control 98%
    Aganirsen sodium scrambled negative control is the sequence scrambled negative control of Aganirsen sodium.
    Aganirsen sodium scrambled negative control
  • HY-153479D
    FAM labled Aganirsen sodium 98%
    FAM labled Aganirsen sodiumis a FAM labled Aganirsen sodium.
    FAM labled Aganirsen sodium
  • HY-153479E
    Cy3 labled Aganirsen sodium 98%
    Cy3 labled Aganirsen sodium is a Cy3 labled Aganirsen sodium.
    Cy3 labled Aganirsen sodium
  • HY-153492C
    Olpasiran sodium scrambled negative control 98%
    Olpasiran sodium scrambled negative control is the sequence scrambled negative control of Olpasiran sodium.
    Olpasiran sodium scrambled negative control
  • HY-153492D
    FAM labled Olpasiran sodium 98%
    FAM labled Olpasiran sodiumis a FAM labled Olpasiran sodium.
    FAM labled Olpasiran sodium
  • HY-153492E
    Cy3 labled Olpasiran sodium 98%
    Cy3 labled Olpasiran sodium is a Cy3 labled Olpasiran sodium.
    Cy3 labled Olpasiran sodium
  • HY-153668A
    Bromodomain inhibitor-12 (edisylate) 2010124-27-1 98%
    Bromodomain inhibitor-12 edisylate (example 303) is a bromodomain inhibitor that can be used in the research of autoimmune and inflammatory diseases.
    Bromodomain inhibitor-12 (edisylate)
  • HY-153841A
    ODN INH-1 sodium
    ODN INH-1 sodium is palindromic and a class R (‘restricted’) inhibitory ODN. ODN INH-1 sodium is a potent inhibitor of TLR9-induced B cells and macrophages
    ODN INH-1 sodium
  • HY-15388S1
    Tazarotene-13C2,d2 2703541-64-2 98%
    Tazarotene-13C2,d2 (AGN 190168-13C2,d2) is the 13C and deuterium labeled isotope of Tazarotene (HY-15388). Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Tazarotene-13C2,d2
Cat. No. Product Name / Synonyms Application Reactivity