2. Others PROTAC Protein Tyrosine Kinase/RTK
  3. Drug Isomer PROTACs Btk
  4. (R,R)-Bexobrutideg

(R,R)-Bexobrutideg  (Synonyms: (R,R)-NX-5948; (R,R)-BTK-IN-24)

Cat. No.: HY-153321A Purity: 98.83% ee.: 98.46%
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(R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker).

For research use only. We do not sell to patients.

(R,R)-Bexobrutideg

(R,R)-Bexobrutideg Chemical Structure

CAS No. : 2649400-33-7

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Based on 1 publication(s) in Google Scholar

Other Forms of (R,R)-Bexobrutideg:

(R,R)-Bexobrutideg Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

(R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker)[1][2][3].

Molecular Weight

806.96

Formula

C42H54N12O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC(C1=C(N=C(N2C[C@H](N3C(N(CC3)C)=O)CCC2)C=N1)NC4=CC=C(C5CCN(CC5)CC6CCN(C7=CN=C(C(N[C@H]8C(NC(CC8)=O)=O)=O)C=C7)CC6)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(R,R)-Bexobrutideg Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-Bexobrutideg2649400-33-7(R,R)-NX-5948(R,R)-BTK-IN-24Drug IsomerPROTACsBtkBruton tyrosine kinasearthritis tumorInhibitorinhibitorinhibit

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