2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P10466A
    KZR-8445 TFA 98%
    KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection.
    KZR-8445 TFA
  • HY-P10612A
    Tetanus toxin (1301-1315) (C. tetani) 158964-53-5 98%
    Tetanus toxin (1301-1315) (C. tetani) is a C-terminal peptide fragment of tetanus toxin heavy chain from C. tetani. Tetanus toxin (1301-1315) (C. tetani) can be used for the researches of infection and immunology.
    Tetanus toxin (1301-1315) (C. tetani)
  • HY-P10707A
    Tpp-CAQK TFA 99.09%
    Tpp-CAQK TAF can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK TFA, with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
    Tpp-CAQK TFA
  • HY-P10739C
    WYRGRLC 1027630-05-2
    WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis.
    WYRGRLC
  • HY-P10897A
    SjDX5-271v
    SjDX5-271v is a negative control of SjDX5-271 (HY-P10897). SjDX5-271 is a small 3 kDa peptide. SjDX5-271 inhibits the TLR4/MyD88/NF-κB signaling pathway. SjDX5-271 induces cell polarization. SjDX5-271 alleviats hepatic inflammation. SjDX5-271 protects mice against liver ischemia-reperfusion injury.
    SjDX5-271v
  • HY-P10937A
    AQP4 (205-215) TFA 98%
    AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO).
    AQP4 (205-215) TFA
  • HY-P11084A
    WT1 126-134 peptide acetate 99.12%
    WT1 126-134 peptide acetate is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide acetate is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide acetate/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide acetate can be used as a vaccine for T cells or as a target for antibodies.
    WT1 126-134 peptide acetate
  • HY-P11208A
    mNLS-CPP-scramble
    mNLS-CPP-scramble is a negative control peptide of mNLS-CPP-WSTF. mNLS-CPP-scramble is promising for research of chronic inflammatory diseases (e.g., MASH, osteoarthritis).
    mNLS-CPP-scramble
  • HY-P11800A
    GPLGVRGC 1257658-47-1 98%
    GPLGVRGC is a cysteine-tagged variant of GPLGVRG (HY-P11800). GPLGVRGC is hydrolyzable by MMP13. GPLGVRGC mediates the disassembly of micelle-exosome systems, enhances chondrocyte endocytosis, and promotes responsive system uptake. GPLGVRGC confers targeted delivery and responsive release properties to micelle-exosome systems. GPLGVRGC is applicable to the research of osteoarthritis.
    GPLGVRGC
  • HY-P1934AR
    Cyclo(L-Phe-L-Pro) (Standard) 3705-26-8
    Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay.
    Cyclo(L-Phe-L-Pro) (Standard)
  • HY-P990064
    Umesolerbart 2456307-11-0 98%
    Umesolerbart (REGN5714) is a Bet v1 specific mAb. Umesolerbart (REGN5714)bind to homologous allergens in Alder, Hazel and hornbeam.
    Umesolerbart
  • HY-P990113
    Anti-Rat TCR gamma/delta Antibody (V65) 98%
    Anti-Rat TCR gamma/delta Antibody (V65) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat TCR gamma/delta. Anti-Rat TCR gamma/delta Antibody (V65) can deplete γδ T cells. Anti-Rat TCR gamma/delta Antibody (V65) can be used for the research of immunology.
    Anti-Rat TCR gamma/delta Antibody (V65)
  • HY-P990128
    Anti-Rat CD80/B7-1 Antibody (3H5) 98%
    Anti-Rat CD80/B7-1 Antibody (3H5) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat CD80/B7-1. Anti-Rat CD80/B7-1 Antibody (3H5) blocks a costimulatory signals for T-cell activation. Anti-Rat CD80/B7-1 Antibody (3H5) can be used for the researches of cancer and immunology.
    Anti-Rat CD80/B7-1 Antibody (3H5)
  • HY-P990138
    Anti-Monkey/Human CD20 Antibody (2H7) 98%
    Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis.
    Anti-Monkey/Human CD20 Antibody (2H7)
  • HY-P990140
    Anti-Rat β-2-Microglobulin Antibody (4C9) 98%
    Anti-Rat β-2-Microglobulin Antibody (4C9) is an anti-rat β-2-Microglobulin IgG1 monoclonal antibody. Anti-Rat β-2-Microglobulin Antibody (4C9) reduces pJNK nuclear translocation and restore SMAD nuclear localization. Anti-Rat β-2-Microglobulin Antibody (4C9) is often used in immunoprecipitation experiments.
    Anti-Rat β-2-Microglobulin Antibody (4C9)
  • HY-P990141
    Anti-Mouse Vβ8 TCR Antibody (F23.1) 98%
    Anti-Mouse Vβ8 TCR Antibody (F23.1) is an anti-mouse Vβ8 TCR IgG2a monoclonal antibody. Anti-Mouse Vβ8 TCR Antibody (F23.1) can clear Vβ8+ T cells to alleviate immune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) can be used for research on autoimmune conditions. Anti-Mouse Vβ8 TCR Antibody (F23.1) is often used in flow cytometry.
    Anti-Mouse Vβ8 TCR Antibody (F23.1)
  • HY-P990142
    Anti-Mouse Vβ4 TCR Antibody (KT4) 98%
    Anti-Mouse Vβ4 TCR Antibody (KT4) is an anti-mouse Vβ4 TCR IgG2b monoclonal antibody. Anti-Mouse Vβ4 TCR Antibody (KT4) can reduce the proportion of Vβ4+ T cells without affecting their function. Anti-Mouse Vβ4 TCR Antibody (KT4) can be used for research on immunology and infection conditions such as virus infection. Anti-Mouse Vβ4 TCR Antibody (KT4) is often used in flow cytometry.
    Anti-Mouse Vβ4 TCR Antibody (KT4)
  • HY-P990146
    Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) 98%
    Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is an anti-mouse/rat/human v-H-Ras IgG2a monoclonal antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) can be used as a control antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is often used for immunofluorescence and immunoprecipitation.
    Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238)
  • HY-P990153
    Anti-Mouse TIM-2 Antibody (RMT2-29) 98%
    Anti-Mouse TIM-2 Antibody (RMT2-29) is a rat-derived Ig2a λ type antibody inhibitor, targeting to mouse TIM-2. Anti-Mouse TIM-2 Antibody (RMT2-29) reacts with mouse T cell immunoglobulin and mucin domain 2 (TIM-2) and blocks TIM-2 signaling. Anti-Mouse TIM-2 Antibody (RMT2-29) can be used for the research of immunology.
    Anti-Mouse TIM-2 Antibody (RMT2-29)
  • HY-P990154
    Anti-Mouse TIM-1/CD365 Antibody (3B3) 98%
    Anti-Mouse TIM-1/CD365 Antibody (3B3) is a rat-derived IgG2a κ type agonistic antibody, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3B3) enhances T-cell proliferation and responses by forming a stable TIM-1 complex and bringing TIM-1 into the T-cell receptor (TCR)-CD3 complex. Anti-Mouse TIM-1/CD365 Antibody (3B3) can be used for the researches of cancer, inflammation and immunology, such as experimental autoimmune encephalomyelitis, B16 F10 tumor and transplant.
    Anti-Mouse TIM-1/CD365 Antibody (3B3)
Cat. No. Product Name / Synonyms Application Reactivity