Anti-Rat CD80/B7-1 Antibody (3H5)
Anti-Rat CD80/B7-1 Antibody (3H5) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat CD80/B7-1. Anti-Rat CD80/B7-1 Antibody (3H5) blocks a costimulatory signals for T-cell activation. Anti-Rat CD80/B7-1 Antibody (3H5) can be used for the researches of cancer and immunology.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Rat
IC50 & Target
CD80/B7-1
In Vitro
Anti-Rat CD80/B7-1 Antibody (3H5) (20 μg/mL, 4 days) inhibits TARS-1-specific proliferation in splenic T cells[1].
Anti-Rat CD80/B7-1 Antibody (3H5) (5 μg/mL, 72 h) blocks co-stimulatory effect t of rCD80/P815 in splenic T cells[3].
Anti-Rat CD80/B7-1 Antibody (3H5) (5 μg/mL, 72 h) inhibits stimulation of allogeneic T cells by F344-S1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Rat CD80/B7-1 Antibody (3H5) (6 mg/kg, i.v., a single dose) blocks mononuclear cell adherence in vasa recta in ischemia/reperfusion injury rat modes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:HTLV-1 tumor rat models[1]
-
Dosage:1 mg/rat
-
Administration:Intraperitoneally injection, every other day for 2 weeks
-
Result:Tumor development consistently and had visible lung metastasis.
Revealed a lymphoma-like appearance and infiltration of tumor cells in the lungs.
Exhibited a markedly reduced level of proliferative and CTL response against TARS-1 cells in splenic T cells.
-
Animal Model:Ischemia/reperfusion injury rat modes[2]
-
Dosage:6 mg/kg
-
Administration:Intravenously injection
-
Result:Showed low serum creatinine and less tubular necrosis.
Had significantly more intact tubules and minimal signs of tubular damage.
Reduced monocytes and T cells in the vasa recta in the ISOM.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
in vitro CD80 blockade; Flow cytometry
Chemical Information
-
Molecular Weight 150 kDa
-
SMILES
[Anti-Rat CD80/B7-1 Antibody (3H5)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hanabuchi S, et al. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. J Virol. 2000 Jan;74(1):428-35. [Content Brief]
[2]. De Greef KE, et al. Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia. Kidney Int. 2001 Oct;60(4):1415-27. [Content Brief]
[3]. Maeda K, et al. Characterization of rat CD80 and CD86 by molecular cloning and mAb. Int Immunol. 1997 Jul;9(7):993-1000. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Rat CD80/B7-1 Antibody (3H5) Related Classifications
HY-P990128 Related Classifications
Powered by Bioz