WT1 126-134 peptide acetate
WT1 126-134 peptide acetate is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide acetate is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide acetate/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide acetate can be used as a vaccine for T cells or as a target for antibodies.
For research use only. We do not sell to patients.
- Purity: 99.12%
- Formula: C52H77N13O12S·xC2H4O2
- Molecular Weight:1108.31 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
WT1 126-134 peptide (100 μg, emulsified with incomplete Freund’s adjuvant, i.p., once a week for 3 weeks) acetate combined with the auxiliary peptide (WT135-52) significantly enhances CTL induction and delays tumor growth induced by mWT1-C1498 cells in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TRAMP-C2 murine prostate cancer cell syngeneic tumor model established in male C57BL/6 mice[1]
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Dosage:100 μg, emulsified with incomplete Freund’s adjuvant
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Administration:Intraperitoneal injection (i.p.), once a week for 2 weeks
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Result:Induced peptide-specific CTL, but was unable to effectively recognize the naturally expressed WT1 protein.
Failed to produce significant anti-tumor effects.
Chemical Information
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Appearance Solid
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Molecular Weight 1108.31 (free base)
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Formula C52H77N13O12S·xC2H4O2
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Sequence
Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu
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Sequence Shortening
RMFPNAPYL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
References
[1]. Shirakawa T, Kitagawa K. Antitumor effect of oral cancer vaccine with Bifidobacterium delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine. Hum Vaccin Immunother. 2018 Jan 2;14(1):159-162. [Content Brief]
[3]. Nakajima H, et al. Identification of mouse helper epitopes for WT1-specific CD4+ T cells. Cancer Immunol Immunother. 2021 Nov;70(11):3323-3335. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WT1 126-134 peptide acetate Related Classifications
HY-P11084A Related Classifications
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