WYRGRLC
WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis.
For research use only. We do not sell to patients.
- CAS No.: 1027630-05-2
- Formula: C43H64N14O9S
- Molecular Weight:953.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
WYRGRLC (0-1 μM) potently and sequence-specifically inhibits the binding of phage displaying WYRGRL to bovine cartilage, with an IC50 of 140 nM[1].
WYRGRLC (15 mg; 1 h) specifically binds to type II collagen α1 chain, which is an abundant extracellular matrix protein in bovine cartilage[1].
WYRGRLC-modified C6@PEG-PA@P-Lipo enhances targeted cellular uptake by rat chondrocytes (RCCs)[2].
WYRGRLC-modified P-Lipo can adhere to the surface layer of porcine cartilage tissue, but its deep penetration ability is limited due to its large particle size[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD rats (210-230 g)[2]
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Dosage:100 μL
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Administration:intra-articular injected, once
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Result:Enabled prolonged joint retention of the RP@PEG-PA@P-Lipo delivery system, contributing to effective suppression of synovitis, preservation of cartilage structure and metabolism, and reduction of chondrocyte apoptosis.
Chemical Information
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CAS No. 1027630-05-2
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Molecular Weight 953.12
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Formula C43H64N14O9S
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Sequence
Trp-Tyr-Arg-Gly-Arg-Leu-Cys
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Sequence Shortening
WYRGRLC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rothenfluh DA, et al. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater. 2008;7(3):248-254. [Content Brief]
[2]. Lin G, et al. Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system. Mater Today Bio. 2024;29:101279. Published 2024 Sep 28. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WYRGRLC Related Classifications
HY-P10739C Related Classifications
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