2. Cytoskeleton Apoptosis
  3. Collagen Apoptosis
  4. WYRGRLC

WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis.

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WYRGRLC

WYRGRLC Chemical Structure

CAS No. : 1027630-05-2

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WYRGRLC Related Antibodies

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Description

WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis[1][2].

In Vitro

WYRGRLC (0-1 μM) potently and sequence-specifically inhibits the binding of phage displaying WYRGRL to bovine cartilage, with an IC50 of 140 nM[1].
WYRGRLC (15 mg; 1 h) specifically binds to type II collagen α1 chain, which is an abundant extracellular matrix protein in bovine cartilage[1].
WYRGRLC-modified C6@PEG-PA@P-Lipo enhances targeted cellular uptake by rat chondrocytes (RCCs)[2].
WYRGRLC-modified P-Lipo can adhere to the surface layer of porcine cartilage tissue, but its deep penetration ability is limited due to its large particle size[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WYRGRLC Related Antibodies
In Vivo

WYRGRLC, as a collagen II targeting peptide modifying liposomes, enables prolonged joint retention of the RP@PEG-PA@P-Lipo delivery system, contributing to effective suppression of synovitis, preservation of cartilage structure and metabolism, and reduction of chondrocyte apoptosis in ACLT-induced OA rats, yielding the lowest OARSI score among all ACLT treatment groups[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (210-230 g)[2]
Dosage: 100 μL
Administration: intra-articular injected, once
Result: Enabled prolonged joint retention of the RP@PEG-PA@P-Lipo delivery system, contributing to effective suppression of synovitis, preservation of cartilage structure and metabolism, and reduction of chondrocyte apoptosis.
Molecular Weight

953.12

Formula

C43H64N14O9S
CAS No.
Sequence

Trp-Tyr-Arg-Gly-Arg-Leu-Cys
Sequence Shortening

WYRGRLC
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Purity & Documentation
References
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WYRGRLC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WYRGRLC1027630-05-2CollagenApoptosisporcine cartilage tissuemurine articular cartilagehuman umbilical vein endothelial cellschondrocytesosteoarthritiscollagen II α1ACLT-induced OA ratsrat cartilage cellsextracellular matrixarticular cartilageInhibitorinhibitorinhibit

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