2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-174622
    Human IL21 mRNA 98%
    Human IL21 mRNA encodes the human interleukin 21 (IL21) protein, a member of the common-gamma chain family of cytokines. IL21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells.
    Human IL21 mRNA
  • HY-174623
    Human IL20RA mRNA 98%
    Human IL20RA mRNA encodes the human interleukin 20 receptor subunit alpha (IL20RA) protein, a member of the type II cytokine receptor family. IL20RA is a subunit of the receptor for interleukin 20, a cytokine that may involve in epidermal function.
    Human IL20RA mRNA
  • HY-174624
    Human IL20 mRNA 98%
    Human IL20 mRNA encodes the human interleukin 20 (IL20) protein, a proinflammatory and angiogenic cytokine that may involves in epidermal function and psoriasis.
    Human IL20 mRNA
  • HY-174625
    Human IL2 mRNA
    Human IL2 mRNA encodes the human interleukin 2 (IL2) protein, a member of the interleukin 2 (IL2) cytokine subfamily. IL2 is produced by activated CD4+ and CD8+ T lymphocytes. It is important for the proliferation of T and B lymphocytes.
    Human IL2 mRNA
  • HY-174626
    Human IL1R1 mRNA 98%
    Human IL1R1 mRNA encodes the human interleukin 1 receptor type 1 (IL1R1) protein, a cytokine receptor that belongs to the interleukin-1 receptor family. IL1R1 is an important mediator involved in many cytokine-induced immune and inflammatory responses.
    Human IL1R1 mRNA
  • HY-174627
    Human IL1B mRNA 98%
    Human IL1B mRNA encodes the human interleukin 1 beta (IL1B) protein, a member of the interleukin 1 cytokine family. IL1B is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
    Human IL1B mRNA
  • HY-174628
    Human IL1A mRNA 98%
    Human IL1A mRNA encodes the human interleukin 1 alpha (IL1A) protein, a member of the interleukin 1 cytokine family. IL1A is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis.
    Human IL1A mRNA
  • HY-174629
    Human IL19 mRNA 98%
    Human IL19 mRNA encodes the human interleukin 19 (IL19) protein, a cytokine that belongs to the IL10 cytokine subfamily. IL19 may play some important roles in inflammatory responses.
    Human IL19 mRNA
  • HY-174630
    Human IL18R1 mRNA 98%
    Human IL18R1 mRNA encodes the human interleukin 18 receptor 1 (IL18R1) protein, a cytokine receptor that belongs to the interleukin 1 receptor family. IL18R1 is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells.
    Human IL18R1 mRNA
  • HY-174632
    Human IL17RA mRNA 98%
    Human IL17RA mRNA encodes the human interleukin 17 receptor subunit alpha (IL17RA) protein, a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.
    Human IL17RA mRNA
  • HY-174633
    Human IL17A mRNA 98%
    Human IL17A mRNA encodes the human interleukin 17A (IL17A) protein, a member of the IL-17 receptor family. IL17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer.
    Human IL17A mRNA
  • HY-174634
    Human IL16 mRNA 98%
    Human IL16 mRNA encodes the human interleukin 16 (IL16) protein, a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication.
    Human IL16 mRNA
  • HY-174635
    Human IL15RA mRNA 98%
    Human IL15RA mRNA encodes the human interleukin 15 receptor subunit alpha (IL15RA) protein, a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. IL15RA is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2.
    Human IL15RA mRNA
  • HY-174636
    Human IL15 mRNA 98%
    Human IL15 mRNA encodes the human interleukin 15 (IL15) protein, a cytokine that regulates T and natural killer cell activation and proliferation. IL15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6.
    Human IL15 mRNA
  • HY-174637
    Human IL13RA2 mRNA 98%
    Human IL13RA2 mRNA encodes the human interleukin 13 receptor subunit alpha 2 (IL13RA2) protein, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
    Human IL13RA2 mRNA
  • HY-174638
    Human IL13RA1 mRNA 98%
    Human IL13RA1 mRNA encodes the human interleukin 13 receptor subunit alpha 1 (IL13RA1) protein, a subunit of the interleukin 13 receptor. IL13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. It has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
    Human IL13RA1 mRNA
  • HY-174639
    Human IL13 mRNA 98%
    Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
    Human IL13 mRNA
  • HY-174640
    Human IL12RB1 mRNA 98%
    Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.
    Human IL12RB1 mRNA
  • HY-174641
    Human IL12B mRNA 98%
    Human IL12B mRNA encodes the human interleukin 12B (IL12B) protein, a subunit of interleukin 12, is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
    Human IL12B mRNA
  • HY-174642
    Human IL12A mRNA 98%
    Human IL12A mRNA encodes the human interleukin 12A (IL12A) protein, a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12A is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells.
    Human IL12A mRNA
Cat. No. Product Name / Synonyms Application Reactivity