2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Art. -Nr. Produktname CAS. Nr. Reinheit Chemische Struktur
  • HY-174637
    Human IL13RA2 mRNA 98%
    Human IL13RA2 mRNA encodes the human interleukin 13 receptor subunit alpha 2 (IL13RA2) protein, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
    Human IL13RA2 mRNA
  • HY-174638
    Human IL13RA1 mRNA 98%
    Human IL13RA1 mRNA encodes the human interleukin 13 receptor subunit alpha 1 (IL13RA1) protein, a subunit of the interleukin 13 receptor. IL13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. It has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
    Human IL13RA1 mRNA
  • HY-174639
    Human IL13 mRNA 98%
    Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
    Human IL13 mRNA
  • HY-174640
    Human IL12RB1 mRNA 98%
    Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.
    Human IL12RB1 mRNA
  • HY-174641
    Human IL12B mRNA 98%
    Human IL12B mRNA encodes the human interleukin 12B (IL12B) protein, a subunit of interleukin 12, is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
    Human IL12B mRNA
  • HY-174642
    Human IL12A mRNA 98%
    Human IL12A mRNA encodes the human interleukin 12A (IL12A) protein, a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12A is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells.
    Human IL12A mRNA
  • HY-174643
    Human IL11RA mRNA 98%
    Human IL11RA mRNA encodes the human interleukin 11 receptor subunit alpha (IL11RA) protein, a member of the hematopoietic cytokine receptor family. IL11RA is essential for the normal development of craniofacial bones and teeth.
    Human IL11RA mRNA
  • HY-174644
    Human IL11 mRNA 98%
    Human IL11 mRNA encodes the human interleukin 11 (IL11) protein, a member of the gp130 family of cytokines. IL11 is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
    Human IL11 mRNA
  • HY-174646
    Human IL10 mRNA
    Human IL10 mRNA is the messenger ribonucleic acid that encodes human IL-10. The expression of IL-10 mRNA is highly inducible and cell type-specific.
    Human IL10 mRNA
  • HY-174656
    Human IFNW1 mRNA 98%
    Human IFNW1 mRNA encodes the human interferon omega 1 (IFNW1) protein, an interferon that possesses antiviral activity.
    Human IFNW1 mRNA
  • HY-174657
    Human IFNLR1 mRNA 98%
    Human IFNLR1 mRNA encodes the human interferon lambda receptor 1 (IFNLR1) protein, a member of the class II cytokine receptor family. IFNLR1, interleukine 10 receptor and beta (IL10RB) form a receptor complex which has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).
    Human IFNLR1 mRNA
  • HY-174658
    Human IFNL3 mRNA 98%
    Human IFNL3 mRNA encodes the human interferon lambda 3 (IFNL3) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL3 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.
    Human IFNL3 mRNA
  • HY-174659
    Human IFNL2 mRNA 98%
    Human IFNL2 mRNA encodes the human interferon lambda 2 (IFNL2) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL2 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.
    Human IFNL2 mRNA
  • HY-174660
    Human IFNL1 mRNA 98%
    Human IFNL1 mRNA encodes the human interferon lambda 1 (IFNL1) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL1 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.
    Human IFNL1 mRNA
  • HY-174661
    Human IFNK mRNA 98%
    Human IFNK mRNA encodes the human interferon kappa (IFNK) protein, a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections.
    Human IFNK mRNA
  • HY-174662
    Human IFNG mRNA 98%
    Human IFNG mRNA encodes the human interferon gamma (IFNG) protein, a member of the type II interferon class. IFNG is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections.
    Human IFNG mRNA
  • HY-174663
    Human IFNE mRNA 98%
    Human IFNE mRNA encodes the human interferon epsilon (IFNE) protein, a cytokine that belongs to the type I class of interferons. IFNE is required for maintaining basal levels of IFN-regulated genes, including 2''-5''-oligoadenylate synthetase, IRF7 and ISG15.
    Human IFNE mRNA
  • HY-174664
    Human IFNB1 mRNA 98%
    Human IFNB1 mRNA encodes the human interferon beta 1 (IFNB1) protein, a cytokine that belongs to the interferon family. IFNB1 belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses.
    Human IFNB1 mRNA
  • HY-174713
    Human FASLG mRNA 98%
    Human FASLG mRNA encodes the human Fas ligand (FASLG) protein, a member of the tumor necrosis factor superfamily. The primary function of the FASLG is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers.
    Human FASLG mRNA
  • HY-174714
    Human FAS mRNA 98%
    Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.
    Human FAS mRNA
Art. -Nr. Produktname / Synonyms Application Reactivity