2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Nom du produit CAS No. Pureté Chemical Structure
  • HY-W291165
    D-DABA 26908-94-1 98%
    D-DABA is the enantiomeric form of L-DABA. D-DABA is also a weak inhibitor of GABA-T, but which has only one twentieth of the potency of the L-isomer in inhibiting GABA uptake.
    D-DABA
  • HY-W319939
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 104236-73-9 98%
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (Compound 5) is a selective lipid peroxidation inhibitor. 3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one is promising for research of diseases related to oxidative stress, such as cardiovascular diseases and neurodegenerative diseases.
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
  • HY-W342471
    Nordiazepam uncyclized intermediate hydrochloride 5504-72-3 99.32%
    Nordiazepam uncyclized intermediate hydrochloride is a prodrug form of Nordiazepam.
    Nordiazepam uncyclized intermediate hydrochloride
  • HY-W342779
    4-Bromoamphetamine hydrochloride 58400-88-7 99.9%
    4-Bromoamphetamine hydrochloride is an amphetamine derivative which acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA) and produces stimulant effects. 4-Bromoamphetamine hydrochloride is highly neurotoxic, producing long-term depletion of serotonin.
    4-Bromoamphetamine hydrochloride
  • HY-W343059
    Gonyautoxin III 60537-65-7 98%
    Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease.
    Gonyautoxin III
  • HY-W345492
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate 858515-82-9 98%
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate (1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester) is an analog of BB-22 that lacks the quinoline group. BB-22 is an analog of cannabinoid.
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate
  • HY-W347202
    N-Caffeoyl serotonin 928765-97-3 98%
    N-Caffeoyl serotonin is a COX-2 inhibitor, with IC50 and Kᵢ values of 42.5 μM and 65.5 μM against COX-2, respectively. N-Caffeoyl serotonin exhibits weak inhibitory activity against BACE1, with an IC50 > 400 μM. N-Caffeoyl serotonin has free radical scavenging activity. N-Caffeoyl serotonin can be used in the research of allergic diseases and Alzheimer's disease.
    N-Caffeoyl serotonin
  • HY-W347776
    1-Benzyl-2-methylpiperazine hydrochloride 93138-53-5 98%
    1-Benzyl-2-methylpiperazine hydrochloride is a piperazine.
    1-Benzyl-2-methylpiperazine hydrochloride
  • HY-W351428
    1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride 95884-48-3 98%
    1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride is a piperazine.
    1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride
  • HY-W353006
    Desmethyl lacosamide 175481-38-6 98%
    Desmethyl lacosamide is a metabolite of Lacosamide (an antiepileptic compound).
    Desmethyl lacosamide
  • HY-W354635
    N-Methyl-2-phenylpropan-1-amine hydrochloride 5969-39-1 98%
    N-Methyl-2-phenylpropan-1-amine hydrochloride is a β-Methylphenethylamine (BMPEA) analog, and has transmitter releasing action at NET and DAT assay.
    N-Methyl-2-phenylpropan-1-amine hydrochloride
  • HY-W354971
    Amisulpride N-oxide 71676-01-2 98%
    Amisulpride N-oxide is a photodegradation product of Amisulpride (HY-14545) (a dopamine D2/D3 receptor antagonist).
    Amisulpride N-oxide
  • HY-W355231
    MEAI hydrochloride 81593-54-6 98%
    MEAI hydrochloride is a derivative of MMAI (HY-W100249), a psychoactive aminoindane.
    MEAI hydrochloride
  • HY-W355311
    3,4-Dimethoxy-α-Pyrrolidinopentiophenone hydrochloride 850351-99-4 98%
    3,4-Dimethoxy-α-Pyrrolidinopentiophenone hydrochloride is an analog of Methylenedioxy Pyrovalerone.
    3,4-Dimethoxy-α-Pyrrolidinopentiophenone hydrochloride
  • HY-W356181
    4,8-DiMeIQx 95896-78-9 98%
    4,8-DiMeIQx is an orally active mutagen, selective dopaminergic neurotoxicant, and DNA damaging agent. 4,8-DiMeIQx can be isolated from cooked beef, sausage, pork, and chicken. 4,8-DiMeIQx induces reverse mutations in *Salmonella typhimurium* TA98 in the presence or absence of S9 mix, and forms DNA adducts in vivo in rat liver. 4,8-DiMeIQx exhibits selective neurotoxicity toward dopaminergic neurons. 4,8-DiMeIQx shows no activity against non-dopaminergic neurons. 4,8-DiMeIQx can be used in studies related to Parkinson's disease and colorectal cancer.
    4,8-DiMeIQx
  • HY-W362839
    Binospirone 102908-59-8 98%
    Binospirone is a 5-HT1A Receptor agonist. Binospirone has anxiolytic activity. Binospirone can be used in the study of movement disorders.
    Binospirone
  • HY-W395204
    1-Phenylethylamine hydrochloride 13437-79-1 98%
    1-Phenylethylamine hydrochloride is a phenethylamine.
    1-Phenylethylamine hydrochloride
  • HY-W409181
    (Rac)-PD 151746 179461-52-0 98%
    (Rac)-PD 151746 is the optically inactive racemate of PD 151746 (HY-19749). PD 151746 is a neuroprotective calpain inhibitor with Ki values of 0.26 μM (u-calpain) and 5.33 μM (m-calpain), respectively.
    (Rac)-PD 151746
  • HY-W509178
    MDBP hydrochloride 38063-96-6 98%
    MDBP hydrochloride is a piperazine.
    MDBP hydrochloride
  • HY-W549985
    Oleoyl-L-carnitine chloride 31062-78-9 98%
    Oleoyl-L-carnitine (chloride) is an active compound and can be used for the research of analytical study.
    Oleoyl-L-carnitine chloride
Cat. No. Nom du produit / Synonyms Application Reactivity