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Cat. No.: HY-W347202

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N-Caffeoyl serotonin

N-Caffeoyl serotonin is a COX-2 inhibitor, with IC₅₀ and Kᵢ values of 42.5 μM and 65.5 μM against COX-2, respectively. N-Caffeoyl serotonin exhibits weak inhibitory activity against BACE1, with an IC₅₀ > 400 μM. N-Caffeoyl serotonin has free radical scavenging activity. N-Caffeoyl serotonin can be used in the research of allergic diseases and Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 928765-97-3
Formula: C₁₉H₁₈N₂O₄
Molecular Weight:338.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

N-Caffeoyl serotonin Chemical Structure

CAS No.: 928765-97-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

COX-2

42.5 μM (IC₅₀)

All COX Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	15 μM Compound: 3, N-caffeoylserotonin	Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days	[PMID: 19524439]
B16	IC₅₀	28 μM Compound: 3, N-caffeoylserotonin	Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation	[PMID: 19524439]

In Vitro

N-caffeoyl serotonin exhibits excellent DPPH free radical scavenging activity (EC50 = 18.9 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 928765-97-3
Molecular Weight 338.36
Formula C₁₉H₁₈N₂O₄
SMILES

C(CNC(/C=C/C1=CC(O)=C(O)C=C1)=O)C=2C=3C(NC2)=CC=C(O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takahashi T, et al. N-Caffeoyl serotonin as selective COX-2 inhibitor. Bioorg Med Chem Lett. 2012;22(7):2494-2496. [Content Brief]

[2]. Takahashi T, Miyazawa M. Serotonin derivatives as inhibitors of beta-secretase (BACE 1). Pharmazie. 2011 Apr;66(4):301-5. PMID: 21612159.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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N-Caffeoyl serotonin

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

N-Caffeoyl serotonin Related Classifications

HY-W347202 Related Classifications