Gonyautoxin III
Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease.
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- CAS. Nr.: 60537-65-7
- Formel: C10H17N7O8S
- Molecular Weight:395.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 60537-65-7
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Molecular Weight 395.35
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Formel C10H17N7O8S
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SMILES
OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@@H]1OS(=O)(O)=O)N)COC(N)=O)O
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Synonyms
GTX-III
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9(1):57-65. [Content Brief]
[2]. Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1689-1693. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Gonyautoxin III Related Classifications
HY-W343059 Related Classifications
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