60537-65-7
Chemical Structure
Gonyautoxin III
Synonym(s): GTX-III
- CAS No.: 60537-65-7
- Formula:C10H17N7O8S
- Molecular Weight:395.35
IUPAC Name: 3-(4-chlorobenzyl)azetidine
InChIKey: ARSXTTJGWGCRRR-LJRZAWCWSA-N
SMILES: OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@@H]1OS(=O)(O)=O)N)COC(N)=O)O
Biological Activity: Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Gonyautoxin III | Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9(1):57-65. [Content Brief]
- [2]. Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1689-1693. [Content Brief]
Keywords
