2. Epigenetics
  3. Glycosyltransferase
  4. SGN-2FF

SGN-2FF est un inhibiteur de fucosylation qui est puissant et oralement actif, inhibe directement l'activité de la fucosyltransférase. SGN-2FF possède une activité antitumorale.

SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity.

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SGN-2FF

SGN-2FF Estructura química

No. CAS : 2089647-47-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
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500 mg   Obtener un presupuesto  

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Based on 2 publication(s) in Google Scholar

Other Forms of SGN-2FF:

SGN-2FF Related Antibodies

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Descripciòn

SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1].

IC50 & Target

Fucosyltransferase[1]
In Vitro

SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGN-2FF Related Antibodies
In Vivo

SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

166.15

Fòrmula

C6H11FO4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

F[C@H]1[C@@H]([C@@H]([C@H](C)OC1O)O)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (300.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 36.67 mg/mL (220.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0187 mL 30.0933 mL 60.1866 mL
5 mM 1.2037 mL 6.0187 mL 12.0373 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (300.93 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.0187 mL 30.0933 mL 60.1866 mL 150.4665 mL
5 mM 1.2037 mL 6.0187 mL 12.0373 mL 30.0933 mL
10 mM 0.6019 mL 3.0093 mL 6.0187 mL 15.0466 mL
15 mM 0.4012 mL 2.0062 mL 4.0124 mL 10.0311 mL
20 mM 0.3009 mL 1.5047 mL 3.0093 mL 7.5233 mL
25 mM 0.2407 mL 1.2037 mL 2.4075 mL 6.0187 mL
30 mM 0.2006 mL 1.0031 mL 2.0062 mL 5.0155 mL
40 mM 0.1505 mL 0.7523 mL 1.5047 mL 3.7617 mL
50 mM 0.1204 mL 0.6019 mL 1.2037 mL 3.0093 mL
60 mM 0.1003 mL 0.5016 mL 1.0031 mL 2.5078 mL
80 mM 0.0752 mL 0.3762 mL 0.7523 mL 1.8808 mL
100 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.5047 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SGN-2FF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGN-2FF2089647-47-0GlycosyltransferaseInhibitorinhibitorinhibit

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Nombre del producto:
SGN-2FF
Cat. No.:
HY-107366
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