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Squalamine

HY-16468

(MSI-1256)

Squalamine

Squalamine Chemical Structure

Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $1312 In-stock
1 mg $500 In-stock
5 mg $950 In-stock
10 mg $1600 In-stock
50 mg $5000 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €1286 In-stock
1 mg €490 In-stock
5 mg €931 In-stock
10 mg €1568 In-stock
50 mg €4900 In-stock
100 mg Get quote
200 mg Get quote

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Product name: Squalamine
Cat. No.: HY-16468

Squalamine Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Squalamine

Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.
IC50 value:
Target:
in vitro: squalamine can strongly displace membrane-bound cationic proteins such as Rac1, a ρ-GTPase recruited to the inner leaflet of the eukaryotic cytoplasmic membrane for the actin remodeling necessary for endocytosis. At concentrations between 20 and 60 μg/mL, squalamine has been shown to inhibit a broad array of growth factor-induced, actin-dependent responses in endothelial cells, including cell migration, cell division, and vascular tube formation in a 3D matrix [1]. Squalamine effectively inhibited HBV replication in human primary hepatocytes when added either during the initial exposure of virus to the cells or at 24 h after infection. A similar study was performed to evaluate the effect of squalamine on the replication of HDV. Squalamine was introduced at 20 μg/mL during HDV exposure, and the effects were measured at day 7 when total RNA was extracted and assayed for HDV RNA sequences [1].
in vivo: one time daily treatment with squalamine (15 or 30 mg/kg per d s.c.) was started beginning on day 1 or 2 after viral administration and continuing until day 8 or 9, respectively. Survival was monitored, and animals that remained alive by day 21 were considered cured [1].
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 627.96 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₃₄H₆₅N₃O₅S
CAS No 148717-90-2
Solvent & Solubility

DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.5925 mL 7.9623 mL 15.9246 mL
5 mM 0.3185 mL 1.5925 mL 3.1849 mL
10 mM 0.1592 mL 0.7962 mL 1.5925 mL

References on Squalamine

Inhibitor Kit

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