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  2. Bacterial
  3. Squalamine lactate

Squalamine lactate (Synonyms: MSI-1256F)

Cat. No.: HY-16467
Handling Instructions

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

For research use only. We do not sell to patients.

Squalamine lactate Chemical Structure

Squalamine lactate Chemical Structure

CAS No. : 320725-47-1

Size Price Stock Quantity
1 mg USD 600 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
50 mg USD 6000 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Squalamine lactate:

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Description

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

In Vitro

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

718.04

Formula

C₃₇H₇₁N₃O₈S

CAS No.

320725-47-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36.66 mg/mL (51.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3927 mL 6.9634 mL 13.9268 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL
10 mM 0.1393 mL 0.6963 mL 1.3927 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

SqualamineMSI-1256FBacterialInhibitorinhibitorinhibit

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Product Name:
Squalamine lactate
Cat. No.:
HY-16467
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