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  3. Squalamine lactate

Squalamine lactate (Synonyms: MSI-1256F)

Cat. No.: HY-16467
Handling Instructions

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

For research use only. We do not sell to patients.

Squalamine lactate Chemical Structure

Squalamine lactate Chemical Structure

CAS No. : 320725-47-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1801 In-stock
Estimated Time of Arrival: December 31
1 mg USD 600 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
50 mg USD 6000 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

In Vitro

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

In Vivo

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

Clinical Trial
Molecular Weight

718.04

Formula

C₃₇H₇₁N₃O₈S

CAS No.

320725-47-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36.66 mg/mL (51.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3927 mL 6.9634 mL 13.9268 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL
10 mM 0.1393 mL 0.6963 mL 1.3927 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

SqualamineMSI-1256FBacterialInhibitorinhibitorinhibit

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Squalamine lactate
Cat. No.:
HY-16467
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