2. Autophagy
  3. Mitophagy
  4. Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate  (Synonyms: Sulfo-N-succinimidyl oleate)

製品番号: HY-112847
取扱説明書 Technical Support

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Sulfosuccinimidyl oleate sodium) that retains the same biological activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 135661-44-8

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of Sulfosuccinimidyl oleate:

Other Forms of Sulfosuccinimidyl oleate:

Sulfosuccinimidyl oleate 関連抗体

Top Publications Citing Use of Products

顧客検証

WB
In Vivo Efficacy Study
IF
Cell Imaging/Staining
In Vivo Imaging

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. Representative C1 BODIPY 500/510C12 staining images were shown. Scale bar=50 μm. The intensity of C1 BODIPY 500/510C12 staining was assessed by Image Pro Plus 6.0.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. The ROS levels were measured by flow cytometry.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    Tp53-deficient ID8 tumor-bearing mice were administered with Niraparib (50 mg/kg) from day 6, and administered with Lipro-1 (10 mg/kg, intraperitoneally, a single dose) and SSO (sulfosuccinimidyl oleate) (50 mg/kg, intragastrically, a single dose) from day 3. Representative actual or bioluminescent images of mice after a 3-week treatment.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 29:101592.  [Abstract]

    AML cells labeled with a chemical probe (alk-C16) for 4 h in the presence of Sulfosuccinimidyl oleate (SSO) (50 μM) were used for palmitoylation assay.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Aug 26;15(8):623.  [Abstract]

    Quantitative analysis of the outer nuclear layer thickness in SSO (sulfosuccinimidyl oleate) (50 mg/kg, oral gavage)-treated MNU-induced WT mouse retina and GW1929 (30 mg/kg, intraperitoneal injection, twice)+SSO treated MNU-induced Trem2−/− mouse retina.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

    体外実験

    Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
    Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sulfosuccinimidyl oleate 関連抗体

    Cell Viability Assay[1]

    Cell Line: BV2 cells
    Concentration: 20 μM and 50 μM
    Incubation Time: 24 hours
    Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

    Western Blot Analysis[1]

    Cell Line: BV2 cells
    Concentration: 50 μM
    Incubation Time: 24 hours
    Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
    体内実験

    Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
    Dosage: 50 mg/kg
    Administration: Administered once by single oral gavage
    Result: Reduced brain damage following ischemia. Attenuated infarct size.
    分子量

    459.60

    分子式

    C22H37NO7S
    CAS 番号
    SMILES

    O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Sulfosuccinimidyl oleate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sulfosuccinimidyl oleate135661-44-8Sulfo-N-succinimidyl oleateMitophagyMitochondrial AutophagyInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    Sulfosuccinimidyl oleate
    製品番号:
    HY-112847
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.