2. Autophagy
  3. Mitophagy
  4. Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate  (Synonyms: Sulfo-N-succinimidyl oleate)

Cat. No.: HY-112847
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Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Sulfosuccinimidyl oleate sodium) that retains the same biological activity.

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No. CAS : 135661-44-8

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Other In-stock Forms of Sulfosuccinimidyl oleate:

Other Forms of Sulfosuccinimidyl oleate:

Sulfosuccinimidyl oleate Related Antibodies

Top Publications Citing Use of Products

39 Publications Citing Use of MCE Sulfosuccinimidyl oleate

WB
In Vivo Efficacy Study
IF
Cell Imaging/Staining
In Vivo Imaging

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. Representative C1 BODIPY 500/510C12 staining images were shown. Scale bar=50 μm. The intensity of C1 BODIPY 500/510C12 staining was assessed by Image Pro Plus 6.0.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 cells were cultured in fatty acid-free media supplemented with 1.0 μL/mL exogenous fatty acids and treated with 10 μМ Niraparib, 100 μМ SSO (sulfosuccinimidyl oleate), or a combination for 72 h. The ROS levels were measured by flow cytometry.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    Tp53-deficient ID8 tumor-bearing mice were administered with Niraparib (50 mg/kg) from day 6, and administered with Lipro-1 (10 mg/kg, intraperitoneally, a single dose) and SSO (sulfosuccinimidyl oleate) (50 mg/kg, intragastrically, a single dose) from day 3. Representative actual or bioluminescent images of mice after a 3-week treatment.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 29:101592.  [Abstract]

    AML cells labeled with a chemical probe (alk-C16) for 4 h in the presence of Sulfosuccinimidyl oleate (SSO) (50 μM) were used for palmitoylation assay.

    Sulfosuccinimidyl oleate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Aug 26;15(8):623.  [Abstract]

    Quantitative analysis of the outer nuclear layer thickness in SSO (sulfosuccinimidyl oleate) (50 mg/kg, oral gavage)-treated MNU-induced WT mouse retina and GW1929 (30 mg/kg, intraperitoneal injection, twice)+SSO treated MNU-induced Trem2−/− mouse retina.

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    Descripciòn

    Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

    In Vitro

    Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
    Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sulfosuccinimidyl oleate Related Antibodies

    Cell Viability Assay[1]

    Cell Line: BV2 cells
    Concentration: 20 μM and 50 μM
    Incubation Time: 24 hours
    Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

    Western Blot Analysis[1]

    Cell Line: BV2 cells
    Concentration: 50 μM
    Incubation Time: 24 hours
    Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
    In Vivo

    Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
    Dosage: 50 mg/kg
    Administration: Administered once by single oral gavage
    Result: Reduced brain damage following ischemia. Attenuated infarct size.
    Peso molecular

    459.60

    Fòrmula

    C22H37NO7S
    No. CAS
    SMILES

    O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    Sulfosuccinimidyl oleate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sulfosuccinimidyl oleate135661-44-8Sulfo-N-succinimidyl oleateMitophagyMitochondrial AutophagyInhibitorinhibitorinhibit

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    Nombre del producto:
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