2. シグナル伝達
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Linker
  5. Acid Cleavable Linker Isoform

Acid Cleavable Linker

Acid-cleavable linkers function as pH-sensitive covalent connections that release therapeutic payloads when exposed to acidic biological environments[1]. Mechanistically, acidic extracellular tumor pH and endosome/lysosome pH provide key triggers for tumor-targeted drug delivery and intracellular drug release[2]. Hydrazone linkers are widely used because they cleave under cancer-cell conditions near pH 5, supporting controlled anticancer drug delivery[3]. Compared with alkylhydrazone linkers, Spiro Diorthoester (SpiDo) showed fast pH-sensitive hydrolysis under mildly acidic conditions, lysosomal hydrolysis, and high human-plasma stability[1]. In polymer and nanomedicine systems, linker chemistry determines whether a tethered payload remains active while attached or releases at the desired site[4]. For cancer applications, stimuli-responsive prodrug nanosystems use activation mechanisms to improve bioavailability, targeting, and reduced side effects[5]. Therefore, acid-cleavable linker design should prioritize plasma stability, acidic-site cleavage, and compatibility with targeted carriers for drug delivery, imaging, and theranostic research[1][4][6].

Acid Cleavable Linker 関連製品 (7):

製品番号 製品名 製品効果 純度
  • HY-136079
    Methyltetrazine-PEG4-hydrazone-DBCO
    Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
  • HY-136061
    BCN-PEG4-HyNic
    BCN-PEG4-HyNic is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BCN-PEG4-HyNic is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • HY-128947
    CL2 Linker
    CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).
  • HY-136075
    HyNic-PEG4-alkyne
    HyNic-PEG4-alkyne is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). HyNic-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-133427
    Propargyl-PEG4-hydrazide
    Propargyl-PEG4-hydrazide is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-hydrazide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-136131
    NH2-PEG4-hydrazone-DBCO
    NH2-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • HY-130954
    Hynic-PEG3-N3
    Hynic-PEG3-N3 is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hynic-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.