Methyltetrazine-PEG4-hydrazone-DBCO
Based on 1 Customer Validation
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- Reinheit: 90%
- Formel: C48H51N9O8
- Molecular Weight:881.97
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Acid Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 881.97
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Formel C48H51N9O8
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Color Purple to purplish red
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SMILES
O=C(CCC(N/N=C\C1=CC=C(C(NCCOCCOCCOCCOCCC(NCC2=CC=C(C3=NN=C(C)N=N3)C=C2)=O)=O)C=C1)=O)N4C5=CC=CC=C5C#CC6=CC=CC=C6C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : ≥ 50 mg/mL (56.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1338 mL | 5.6691 mL | 11.3383 mL | 28.3456 mL |
| 5 mM | 0.2268 mL | 1.1338 mL | 2.2677 mL | 5.6691 mL | |
| 10 mM | 0.1134 mL | 0.5669 mL | 1.1338 mL | 2.8346 mL | |
| 15 mM | 0.0756 mL | 0.3779 mL | 0.7559 mL | 1.8897 mL | |
| 20 mM | 0.0567 mL | 0.2835 mL | 0.5669 mL | 1.4173 mL | |
| 25 mM | 0.0454 mL | 0.2268 mL | 0.4535 mL | 1.1338 mL | |
| 30 mM | 0.0378 mL | 0.1890 mL | 0.3779 mL | 0.9449 mL | |
| 40 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7086 mL | |
| 50 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5669 mL |
Methyltetrazine-PEG4-hydrazone-DBCO Related Classifications
HY-136079 Related Classifications
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