2. シグナル伝達
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Linker
  5. ADC Linker Isoform

ADC Linker

 

ADC Linker 関連製品 (526):

製品番号 製品名 製品効果 純度
  • HY-151794
    DACN(Ms) hydrochloride
    DACN(Ms) hydrochloride (compound 1ba) is a click chemistry reagent containing cyclononyne alkyne. DCN(Ms) hydrochloride has high thermal stability, chemical stability, water solubility, and high reactivity for cycloaddition reactions.
  • HY-151782
    H-(Gly)3-Lys(N3)-OH
    The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
  • HY-151691
    Trisulfo-Cy3 Methyltetrazine
    Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures.
  • HY-152919
    Mal-amide-PEG8-Val-Cit-PAB-OH
    Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
  • HY-P2376
    Arg-Phe-Asp-Ser
    Arg-Phe-Asp-Ser is a cleavable ADC linker.
  • HY-101157R
    Propargyl-PEG5-acid (Standard)
    Propargyl-PEG5-acid (Standard) is the analytical standard of Propargyl-PEG5-acid (HY-101157). This product is intended for research and analytical applications. Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-151733
    Fmoc-D-Dbu(N3)-OH
    Fmoc-D-Dbu(N3)-OH is a click chemistry reagent containing an Azide. Fmoc-D-Dbu(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • HY-151842
    Fmoc-EDA-N3
    Fmoc-EDA-N3 is a click chemistry reagent containing an azide group. Fmoc-EDA-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • HY-W800622
    Fmoc-PEG4-Val-Cit-PAB-OH
    Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
  • HY-151816
    alpha-Man-TEG-N3
    alpha-Man-TEG-N3 is a click chemistry reagent containing an azide group. alpha-Man-TEG-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • HY-151780
    Fmoc-L-Dap(Pentynoyl)-OH
    Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Dap(Pentynoyl)-OH serves as an amino acid building block for introducing alkyne functions into peptide sequences by standard Fmoc/tBu protocols. The alkyne residue can be engaged for copper catalyzed click reaction with organic azides or with tetrazines for copper-free conjugations. Fmoc-L-Dap(Pentynoyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-41064
    N-Boc-N-methyl-D-Valaldehyde
    N-Boc-N-methyl-D-Valaldehyde is an ADC linker with a BOC protecting group.
  • HY-100216R
    SPDP (Standard)
    SPDP (Standard) is the analytical standard of SPDP (HY-100216). This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
  • HY-177502
    NHS-cBu-Cit-PAB
    NHS-cBu-Cit-PAB is an intermediate of ADC linker. NHS-cBu-Cit-PAB can be used for synthesis of antibody-drug conjugates (ADCs).
  • HY-151790
    Alkyne-SS-COOH
    Alkyne-SS-COOH is a click chemistry reagent containing an alkyne group. Alkyne-SS-COOH can be used for the research of various biochemical.
  • HY-177942
    Azide-C5-amide-tri-SA-bis(amide-PBA)
    Azide-C5-amide-tri-SA-bis(amide-PBA) (compound 15) is a linker targeting eye tissue specific protein, can be used for oligonucleotide coupling .
  • HY-W800814
    Azido-PEG8-Amido-Val-Cit-PAB
    Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose.
  • HY-151814
    (2S,4S)-Fmoc-L-Pro(4-NHPoc)-OH
    (2S,4S)-Fmoc-L-Pro(4-NHPoc)-OH is a click chemistry reagent containing an azide group.
  • HY-W540192
    SCO-PEG2-Maleimide
    SCO-PEG2-Maleimide is an ADC Linker containing 3 PEG units. SCO-PEG2-Maleimide can be used as a copper-free click chemical reagent for catalyst-free click reactions. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
  • HY-164273
    Azidoacetyl-Val-Cit-PAB-OH
    Azidoacetyl-Val-Cit-PAB-OH is a cleavable ADC linker.