FAAH
Fatty acid amide hydrolase
FAAH (Fatty acid amide hydrolase) is a membrane-bound protein belonging to serine hydrolase family of enzymes.FAAH is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). FAAH plays a significant role in termination of signalling of a class of bioactive lipids called fatty acid amides (FAAs) both in the central nervous system (CNS) and peripheral tissues.
FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.
All Product Categories
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FAAH Related Products (106)
Related Products (106)
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Antibodies (1)
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URB524
0 ImagesCat. No.: HY-116798CAS No.: 546141-07-5
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FAAH inhibitor 1 (Standard)
0 ImagesCat. No.: HY-10862RCAS No.: 326866-17-5Synonyms: Benzothiazole analog 3 (Standard)FAAH inhibitor 1 (Standard) is the analytical standard of FAAH inhibitor 1 (HY-10862). This product is intended for research and analytical applications. FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC50 value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research.
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NRMA-8
0 ImagesCat. No.: HY-164506CAS No.: 2375659-15-5NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas.
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OL-135
0 ImagesCat. No.: HY-10869CAS No.: 681135-77-3OL-135 is a CNS penetrant, selective, and reversible of FAAH inhibitor. OL-135 exhibits analgesic activity.
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FAAH-IN-8
0 ImagesCat. No.: HY-157132CAS No.: 2867633-84-7FAAH-IN-8 (compound 11) is a competitive inhibitor of FAAH with an IC50 value of 6.7 nM and a Ki value of 5 nM. FAAH-IN-8 has high blood-brain permeability and a significant antioxidant profile with no neurotoxicity.
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FAAH inhibitor 2
0 ImagesFAAH inhibitor 2 (Compound 17b) is an irreversible fatty acid amide hydrolase (FAAH) inhibitor, with an IC50 of 0.153 μM.
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LY2183240 (Standard)
0 ImagesCat. No.: HY-10865RCAS No.: 874902-19-9LY2183240 (Standard) is the analytical standard of LY2183240 (HY-10865). This product is intended for research and analytical applications. LY2183240 is a highly potent blocker of anandamide uptake (IC50= 270 pM; Ki=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC50s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KiAA1363, respectively .
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Arachidonamide
0 ImagesCat. No.: HY-111293CAS No.: 85146-53-8Synonyms: Arachidonoyl amine; Arachidonic acid amideArachidonamide is substrate of anandamide amidohydrolase.
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FAAH-IN-9
0 ImagesCat. No.: HY-121090CAS No.: 288862-89-5FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM.
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Arachidonoyl m-nitroaniline
0 ImagesCat. No.: HY-158784CAS No.: 1175954-87-6
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MK-3168 (12C)
0 ImagesCat. No.: HY-161965CAS No.: 1242441-26-4
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CAY10435
0 ImagesCat. No.: HY-120650CAS No.: 288862-73-7
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JNJ-42165279 dihydrochloride
0 ImagesCat. No.: HY-19636ACAS No.: 1346528-51-5JNJ-42165279 (dihydrochloride) is aFAAHinhibitor with IC50 of 70 nM and 313 nM for hFAAH and rFAAH, respectively.
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URB-597 (Standard)
0 ImagesSynonyms: KDS-4103 (Standard)URB-597 (Standard) is the analytical standard of URB-597. This product is intended for research and analytical applications. URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity.
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AZ513
0 ImagesCat. No.: HY-169603CAS No.: 1335231-15-6AZ513 is a reversible FAAH inhibitor with an IC50s of 551 nM and 27 nM for human FAAH and rat FAAH, respectively. AZ513 inhibits Anandamide (HY-10863) hydrolysis in human FAAH-transfected HEK293 cells (IC50 of 360 nM).
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FAAH-IN-1 (Standard)
0 ImagesCat. No.: HY-111389RCAS No.: 1242441-47-9
