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Cat. No.: HY-120481

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JNJ-40413269

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC₅₀ of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats.

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CAS No.: 1184847-16-2
Formule: C₁₉H₁₅ClF₃N₃O
Masse moléculaire:393.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JNJ-40413269 Chemical Structure

CAS No.: 1184847-16-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC₅₀: 28 nM (hFAAH), 270 nM (rFAAH)^[1]

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Chemical Information

CAS No. 1184847-16-2
Masse moléculaire 393.79
Formule C₁₉H₁₅ClF₃N₃O
SMILES

FC(F)(F)C1=CC=C(C2=NC=NC(NC[C@H](O)C3=CC=CC=C3)=C2)C=C1Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Keith JM, et al., 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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JNJ-40413269

Voir tous les produits spécifiques à Isoform FAAH