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Cat. No.: HY-19636A

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JNJ-42165279 dihydrochloride

JNJ-42165279 (dihydrochloride) is aFAAHinhibitor with IC₅₀ of 70 nM and 313 nM for hFAAH and rFAAH, respectively.

For research use only. We do not sell to patients.

CAS No.: 1346528-51-5
Formula: C₁₈H₁₉Cl₃F₂N₄O₃
Molecular Weight:483.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

JNJ-42165279 dihydrochloride Chemical Structure

CAS No.: 1346528-51-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

JNJ-42165279 (dihydrochloride) is aFAAHinhibitor with IC₅₀ of 70 nM and 313 nM for hFAAH and rFAAH, respectively^[1].

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1346528-51-5
Molecular Weight 483.72
Formula C₁₈H₁₉Cl₃F₂N₄O₃
SMILES

O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keith JM, et al. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279. ACS Med Chem Lett. 2015;6(12):1204-1208. Published 2015 Nov 2. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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