2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-135713
    Penoxsulam
    		Inhibitor
    Penoxsulam is an acetolactate synthase (ALS) inhibitor herbicide. Penoxsulam inhibits Candida auris acetohydroxyacid synthase (AHAS) with a Ki value of <32 nM. Penoxsulam can be used for postemergence control of annual grasses, sedges, and broadleaf weeds in rice culture. Penoxsulam can be used for the study of Candida auris infections.
    Penoxsulam
  • HY-135549R
    Fluxapyroxad (Standard)
    		Inhibitor
    Fluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
    Fluxapyroxad (Standard)
  • HY-N7364S
    (E)-β-Farnesene-d6
    		Inhibitor
    (E)-β-Farnesene-d6 is deuterated labeled (E)-β-Farnesene (HY-N7364). (E)-β-Farnesene (trans-β-Farnesene) is an aphid alarm pheromone, which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene shows good binding score with a value of -30.64 kcal/mol to the CDK2 receptor. (E)-β-Farnesene also exhibits good affinity to odorant-binding protein 3 (OBP3). (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.
    (E)-β-Farnesene-d<sub>6</sub>
  • HY-117496
    Ampelopsin A
    		Inhibitor
    Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects.
    Ampelopsin A
  • HY-N8015S2
    Octanal-d4
    		Inhibitor
    Octanal-d4 is deuterated labeled Octanal (HY-N8015). Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL.
    Octanal-d<sub>4</sub>
  • HY-B0845R
    Prochloraz (Standard)
    		Inhibitor
    Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
    Prochloraz (Standard)
  • HY-N14810
    Neobulgarone D
    		Inhibitor
    Neobulgarone D is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone D can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone D
  • HY-136756
    CYP51-IN-6
    		Inhibitor
    CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-6
  • HY-N14329
    Maniwamycin B
    		Inhibitor
    Maniwamycin B has anti-fungal effect.
    Maniwamycin B
  • HY-W983893
    7-Hydroxytropolone
    		Inhibitor
    7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic with anti-Gram-positive bacteria, negative bacteria, yeast and fungi activity, and has the effect of inhibiting 2''-O-Adenylyltransferase.
    7-Hydroxytropolone
  • HY-114927
    (±)-Dunnione
    		Inhibitor
    (±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
    (±)-Dunnione
  • HY-176417
    Antifungal agent 132
    		Inhibitor
    Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a Ki of 180 pM.
    Antifungal agent 132
  • HY-W016288R
    Naphthalene-2,3-dicarboxaldehyde (Standard)
    		Inhibitor
    Naphthalene-2,3-dicarboxaldehyde (Standard) is the analytical standard for Naphthalene-2,3-dicarboxaldehyde (HY-W016288). This product is for research and analytical applications. Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis.
    Naphthalene-2,3-dicarboxaldehyde (Standard)
  • HY-157027
    Antifungal agent 85
    		Inhibitor
    Antifungal agent 85 (compound 24f) is a potent antibacterial compound with the minimum inhibitory concentration (MIC) values between 2.5 and 10 μM against various Gram-positive bacteria.
    Antifungal agent 85
  • HY-122451R
    Ofurace (Standard)
    		Inhibitor
    Ofurace (Standard) is the analytical standard of Ofurace. This product is intended for research and analytical applications. Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth.
    Ofurace (Standard)
  • HY-N14150
    Darlucin A
    		Inhibitor
    Darlucin A has antibacterial and fungi activity, and weak cytotoxicity.
    Darlucin A
  • HY-129234
    Mazethramycin
    		Inhibitor
    Mazethramycin is an antitumor antibiotic that exerts its antitumor effect by interfering with cellular DNA replication and RNA synthesis. Mazethramycin can be used in cancer research.
    Mazethramycin
  • HY-165154
    Cyclamidomycin
    		Inhibitor
    Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml).
    Cyclamidomycin
  • HY-N14408
    Fosfazinomycin B
    		Inhibitor
    Fosfazinomycin B has the activity of resisting plant pathogenic fungi such as Xanthomonas oryzae.
    Fosfazinomycin B
  • HY-N14266
    Hypelcin A-IV
    		Inhibitor
    Hypelcin A-IV has anti-Gram-negative bacterial and fungal activity.
    Hypelcin A-IV
Cat. No. 상품명 / Synonyms Application Reactivity