2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16321R
    Micafungin sodium (Standard)
    		Inhibitor
    Micafungin (sodium) (Standard) is the analytical standard of Micafungin (sodium). This product is intended for research and analytical applications. Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
    Micafungin sodium (Standard)
  • HY-N15023
    Azoxybacilin
    		Inhibitor
    Azoxybacilin can inhibit the sulfur fixation reaction in methionine biosynthesis and has strong anti-filamentous fungal activity.
    Azoxybacilin
  • HY-106333
    Irtemazole
    		Inhibitor
    Irtemazole is an orally active antifungal agent. Irtemazole possesses uricosuric effect. Irtemazole is used in the research for blastomycosis, histoplasmosis, and aspergillosis.
    Irtemazole
  • HY-N2512R
    1-Monomyristin (Standard)
    		Inhibitor
    1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans.
    1-Monomyristin (Standard)
  • HY-W009815
    δ-Dodecalactone
    		Inhibitor 99.19%
    δ-Dodecalactone can be obtained from L. plantarum AF1. δ-Dodecalactone exhibits potent antifungal activity against molds Aspergillus flavus, A. fumigatus, A. petrakii, A. ochraceus, A. nidulans, and Penicillium roqueforti. δ-Dodecalactone is a flavoring compound.
    δ-Dodecalactone
  • HY-17521R
    Flumorph (Standard)
    		Inhibitor
    Flumorph (Standard) is the analytical standard of Flumorph. This product is intended for research and analytical applications. 0
    Flumorph (Standard)
  • HY-B0293R
    Butoconazole nitrate (Standard)
    		Inhibitor
    Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis.
    Butoconazole nitrate (Standard)
  • HY-179518
    Antifungal agent 140
    		Inhibitor
    Antifungal agent 140 (compound 5p) is a potent antifungal agent with broad-spectrum antifungal activity. Antifungal agent 140 exerts a dual mechanism by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and the ergosterol biosynthesis pathway. Antifungal agent 140 enhances survival, reduces fungal load in the kidneys, and strengthens host immune responses in a murine model of systemic candidiasis. Antifungal agent 140 can be used for research of resistant fungal infections.
    Antifungal agent 140
  • HY-165017
    Etheroleic acid
    		Inhibitor
    Etheroleic acid has antifungal activity against the powdery mildew B. graminis on the second leaves of barley seedlings. Etheroleic acid is a metabolite of Linolenic acid.
    Etheroleic acid
  • HY-125358
    Dactylfungin B
    		Inhibitor
    Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL.
    Dactylfungin B
  • HY-136763
    CYP51-IN-13
    		Inhibitor
    CYP51-IN-2 (compound 1m), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-13
  • HY-W072994
    Copper naphthenate
    		Inhibitor
    Copper naphthenate is an organocopper compound with the properties of a fungicide, preservative, oil-borne protectant, and toxicant. Copper naphthenate increases serum and urine copper levels in exposed populations, causes skin irritation, and induces intraperitoneal toxicity in rats. Copper naphthenate inhibits the growth of decay fungi and molds on moso bamboo, kills the free-living stages of Ichthyophthirius multifiliis, and controls wood-boring insects and termites.
    Copper naphthenate
  • HY-N14427
    Concanamycin G
    		Inhibitor
    Concanamycin G has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
    Concanamycin G
  • HY-W753375R
    Fluindapyr (Standard)
    		Inhibitor
    Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.
    Fluindapyr (Standard)
  • HY-N14489
    Neocopiamycin A
    		Inhibitor
    Neocopiamycin A is broad-spectrum resistant to Gram-positive bacteria, yeast and filamentous fungi.
    Neocopiamycin A
  • HY-119830
    Azaconazole
    		Inhibitor
    Azaconazole is an agriculture fungicide, and can be used for controlling powdery mildew on crops and bean rust.
    Azaconazole
  • HY-133216
    Bupirimate
    		Inhibitor 99.77%
    Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew.
    Bupirimate
  • HY-169203
    Antifungal agent 119
    		Inhibitor
    Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions..
    Antifungal agent 119
  • HY-W010790
    Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
    		Inhibitor
    Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride is a quaternary ammonium silane monomer-based disinfectant/antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as fungicidal activity against Candida albicans in solution; it can form a hydrophobic glass coating that displays bactericidal activity against Gram-positive and Gram-negative bacteria but has limited fungicidal activity against Candida albicans.
    Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
  • HY-178717
    WML-01
    		Inhibitor
    WML-01 is a fungicide with EC50s of 0.079, 0.72 and 2.02 μg/mL against F. graminearum, F. fujikuroi and S. sclerotiorum. WML-01 disrupts the cell membrane of F. graminearum and induces deposition of lipid droplets. WML-01 inhibits Deoxynivalenol (DON) (HY-N6684) biosynthesis with no cross-resistance and strongly suppresses ribosomal subunit assembly, impairing protein synthesis. WML-01 effectively controls the fusarium head blight (FHB) epidemic.
    WML-01
Cat. No. Product Name / Synonyms Application Reactivity