Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride 

Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride is a quaternary ammonium silane monomer-based disinfectant/antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as fungicidal activity against Candida albicans in solution; it can form a hydrophobic glass coating that displays bactericidal activity against Gram-positive and Gram-negative bacteria but has limited fungicidal activity against Candida albicans^[1].

Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (24 h) acts as a bactericide against Staphylococcus aureus (MIC = 3.9 μg/mL, MBC = 3.9 μg/mL) and Escherichia coli (MIC = 62.5 μg/mL, MBC = 62.5 μg/mL), and also functions as a fungicide against Candida albicans (MIC = 15.6 μg/mL, MFC = 62.5 μg/mL)^[1].
Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (62.5 μg/mL; 24 h) exhibits high toxicity toward human skin fibroblasts, HaCaT keratinocytes and HEK293 cells^[1].
The coating formed on the surfaces of glass coverslips and Lava™ Ultimate dental restorative material by dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (10 mg/mL; 24 h) exhibits strong antibacterial activity against Staphylococcus aureus and Escherichia coli, but shows negligible activity against Candida albicans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.29

C₂₆H₅₈ClNO₃Si

27668-52-6

[Cl-].O(C)[Si](OC)(OC)CCC[N+](C)(C)CCCCCCCCCCCCCCCCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li H, et al. High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers. Biomater Sci. 2016;4(2):299-309.  [Content Brief]