2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-179270
    CYP51-IN-30
    		Inhibitor
    CYP51-IN-30 is a CYP51 inhibitor and fungicidal agent. CYP51-IN-30 inhibits CYP51 activity. CYP51-IN-30 displays potent fungicidal activity with an EC50 value of 2.97 mg/L against S. sclerotiorum.
    CYP51-IN-30
  • HY-W714300
    Nuarimol
    		Inhibitor
    Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.
    Nuarimol
  • HY-125487
    Appenolide A
    		Inhibitor
    Appenolide A is an antifungal furanones that can be isolated from the coprophilous fungus Podospora appendiculata.
    Appenolide A
  • HY-N14912
    β-Prumycin hydrochloride
    		Inhibitor
    β-Prumycin hydrochloride is a carbohydrate antibiotic. β-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
    β-Prumycin hydrochloride
  • HY-175038
    Oomycete-IN-1
    		Inhibitor
    Oomycete-IN-1 (Compound X4) is a selective inhibitor targeting the PH domain of PcORP1 in Phytophthora species. Oomycete-IN-1 shows EC50 values ranging from 1 to 4 μg/mL against six oomycetes. Oomycete-IN-1 disrupts lipid transport and metabolism, leading to mycelium hyperplasia and cell membrane ruffling in P. capsici. Oomycete-IN-1 can be used in the research of preventing and controlling oomycete diseases (such as P. capsici infection).
    Oomycete-IN-1
  • HY-N4102R
    5,7-Dihydroxy-4-methylcoumarin (Standard)
    		Inhibitor
    5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
    5,7-Dihydroxy-4-methylcoumarin (Standard)
  • HY-175699
    Antimicrobial agent-42
    		Inhibitor
    Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candida albicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach.
    Antimicrobial agent-42
  • HY-136752
    CYP51-IN-2
    		Inhibitor
    CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-2
  • HY-126770
    Rhizocticin A
    		Inhibitor
    Rhizocticin A is an antifungal phosphono-oligopeptide against Ascodesmis, Plicaria, Rhizoctonia with MIC of 3.5 μg/mL. Rhizocticin A produces toxic L-2-Amino-5-phospho-3-cis-pentenoic acid (L-APPA), which may interfere with cell metabolism.
    Rhizocticin A
  • HY-125569
    Leucomycin A5
    		Inhibitor
    Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively.
    Leucomycin A5
  • HY-W167979
    3-Amino-1,2,4-triazin-5(2H)-one
    		Inhibitor
    3-Amino-1,2,4-triazin-5(2H)-one is an organic compound belonging to the triazine family. 3-Amino-1,2, 4-Triazin-5 (2H)-one and its derivatives may have a variety of biological activities, such as antibacterial, antifungal, antiviral, or antitumor but the specific activity depends on its chemical structure and functional groups. 3-Amino-1,2, 4-Triazin-5 (2H)-one is a lead compound with a wide range of applications.
    3-Amino-1,2,4-triazin-5(2H)-one
  • HY-N15343
    Albiducin A
    		Inhibitor
    Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC50 values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases.
    Albiducin A
  • HY-121766
    Iprovalicarb
    		Inhibitor
    Iprovalicarb (Fencaramid; SZX-0722) is a fungicide that can be used for the study of fungal diseases in the wine sector.
    Iprovalicarb
  • HY-W514721
    D13
    		Inhibitor
    D13, an Acylhydrazones derivative, possesses antifungal activity. D13 is effective against murine sporotrichosis.
    D13
  • HY-W714076R
    Ametoctradin (Standard)
    		Inhibitor
    Ametoctradin (Standard) is the analytical standard of Ametoctradin. This product is intended for research and analytical applications. Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
    Ametoctradin (Standard)
  • HY-116568R
    Prothioconazole (Standard)
    		Inhibitor
    Prothioconazole (Standard) is the analytical standard of Prothioconazole. This product is intended for research and analytical applications. Prothioconazole is a triazolinthione fungicide. Prothioconazole is a CYP51 inhibitor.
    Prothioconazole (Standard)
  • HY-N14442
    Haliangicin B
    		Inhibitor
    Haliangicin B has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin B
  • HY-N14159
    Epelmycin E
    		Inhibitor
    Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin E
  • HY-N12267A
    Terrestribisamide
    		Inhibitor
    Terrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects.
    Terrestribisamide
  • HY-N14990
    Pneumocandin C0
    		Inhibitor
    Pneumocandin C0 is the isomer of Pneumocandin B0 (HY-17578) with antifungal activity, which is found by carrying out fermentations of Glarea lozoyensis at a high residual fructose concentration.
    Pneumocandin C0
Cat. No. Product Name / Synonyms Application Reactivity