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  4. Nuarimol

Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.

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Nuarimol

Nuarimol Chemical Structure

CAS No. : 63284-71-9

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Description

Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury[1].

In Vivo

Nuarimol (31.5-125 mg/kg; p.o.; once daily; for 1-5 consecutive days) induces dose-dependent, reversible hepatic effects in male Wistar rats, including increased p-nitroanisole O-demethylase activity, transient hepatocellular proliferation, and reversible hepatomegaly. Histological changes indicate that this is a regenerative response rather than a direct mitogenic response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pzh:WIS (male, 200-210 g, acclimatized for 14 days under controlled environmental conditions)[1]
Dosage: 31.5 mg/kg; 62.5 mg/kg; 125 mg/kg
Administration: p.o.; once daily; 1, 3, or 5 consecutive days
Result: Did not change liver weight.
Significantly increased p-nitroanisole O-demethylase activity.
Significantly increased the number of mitotic figures.
Observed cytoplasmic vacuolization (likely fatty changes) and focal hepatocyte destruction (suggesting piecemeal necrosis).
Molecular Weight

314.74

Formula

C17H12ClFN2O
CAS No.
SMILES

FC1=CC=C(C=C1)C(O)(C=2C=NC=NC2)C=3C=CC=CC3Cl
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References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nuarimol63284-71-9Fungalcytochrome P-450bbinuclear hepatocytep-nitroanisolep-nitroanisole O-demethylasehepatocellular damageDNA synthesishepatomegalyhepatocyte proliferationrat livermale Wistar ratsInhibitorinhibitorinhibit

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