Rhizocticin A
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- CAS No.: 114301-25-6
- Formule: C11H22N5O6P
- Masse moléculaire:351.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Synthetic Rhizocticin A (3.5-1050 μg/L; 24 h) does not exhibit significant antifungal activity against Candida albicans, Saccharomyces cerevisiae, or Candida glabrata when tested at concentrations up to 1050 μg/L for 24 h in liquid media[1].
Rhizocticin A (11-3500 ng/disk) potently inhibits the growth of diverse fungal strains, including Saccharomyces cerevisiae Tü 125, Saccharomycopsis lipolytica Tü 8097, and Schizosaccharomyces pombe Tü 251 with an MIC of 0.35 μg/mL, and Ascodesmis sphaerospora Tü 147, Nematospora coryli Tü 194, and Basidiobolus microsporus Tü 174 with an MIC of 3.5 μg/mL, while showing variable activity against other filamentous and basidiomycete fungi[2].
Rhizocticin A (0.110 mg/mL)'s antifungal activity against Saccharomyces cerevisiae Tü 125 and Paecilomyces variotii Tü 137 is competitively antagonized by specific oligopeptides (including Arg-Leu-acetate, Arg-Tyr, and Phe-Gly-Gly) and L-/D-cystine, and non-competitively antagonized by Thr, homoserine, and Trp, indicating uptake via oligopeptide transporters and potential interference with threonine-related metabolism[2].
Rhizocticin A (1 mg/mL; 36 μg/mL) does not inhibit the growth of 18 tested bacterial strains or Paramecium caudatum at the tested concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Caenorhabditis elegans (fed on Escherichia coli strain 645)[2]
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Dosage:3.5 μg/mL; 10 μg/mL
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Administration:in culture medium; continuous exposure
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Result:Reduced nematode motility at 3.5 μg/mL.
Killed all test animals at 10 μg/mL.
Failed to have toxic effects prevented by 150 μg/mL threonine added to the culture medium.
Chemical Information
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CAS No. 114301-25-6
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Masse moléculaire 351.30
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Formule C11H22N5O6P
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SMILES
O=C(O)[C@H](/C=C\CP(O)(O)=O)NC([C@H](CCCNC(N)=N)N)=O
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Structure Classification
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Initial Source
Bacillus subtilis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rhizocticin A Related Classifications
HY-126770 Related Classifications
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