2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N6626R
    Pyraclostrobin (Standard)
    		Inhibitor
    Pyraclostrobin (Standard) is the analytical standard of Pyraclostrobin. This product is intended for research and analytical applications. Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.
    Pyraclostrobin (Standard)
  • HY-19404
    Embeconazole
    		Inhibitor
    Embeconazole (CS-758; R-120758) is an antifungal agent against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively.
    Embeconazole
  • HY-141811
    Antifungal agent 11
    		Inhibitor
    Antifungal agent 11 shows the promising antifungal activity.
    Antifungal agent 11
  • HY-B0843S
    Metalaxyl-13C6
    		Inhibitor 98.4%
    Metalaxyl-13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
    Metalaxyl-<sup>13</sup>C<sub>6</sub>
  • HY-111968R
    Orysastrobin (Standard)
    		Inhibitor
    Orysastrobin (Standard) is the analytical standard of Orysastrobin. This product is intended for research and analytical applications. Orysastrobin, a “quinone outside inhibitor” (QoI)-type fungicide, has excellent fungicidal efficacy against leaf and panicle blast and against sheath blight in rice.
    Orysastrobin (Standard)
  • HY-147814
    KFU-127
    		Inhibitor
    KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells. KFU-127 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    KFU-127
  • HY-100069
    Fluazinam impurity 1
    		Inhibitor
    Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against Sphaerotheca fuliginea, Pyricularia oryzae and Rhizoctonia solani.
    Fluazinam impurity 1
  • HY-155711
    Antifungal agent 69
    		Inhibitor
    Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candida albicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity.
    Antifungal agent 69
  • HY-W023253
    Biclotymol
    		Inhibitor
    Biclotymol is an antimicrobial agent against gram-positive cocci. Biclotymol inhibits Streptococcus pneumoniae and Haemophilus influenzae, with MIC of 150 and 150 μM. Biclotymol exhibits anti-inflammatory and analgesic activity and ameliorates the otolaryngology infection and throat sore.
    Biclotymol
  • HY-N16051
    Bromoflavone
    		Inhibitor
    Bromoflavone (CJ-19784) is a flavone that can be isolated from Aspergillus candidus. Bromoflavone shows anti-Mtb activity with an MIC90 value of 1.2 μM. Bromoflavone is also an antifungal agent. Bromoflavone inhibits the growth of pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with IC50 values of 0.11, 20 and 0.54 μg/mL, respectively..
    Bromoflavone
  • HY-113362R
    Petroselinic acid (Standard)
    		Inhibitor
    Petroselinic acid (Standard) is the analytical standard of Petroselinic acid. This product is intended for research and analytical applications. Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid is used as substrate for sophorolipid fermentation. Petroselinic acid inhibits the biofilm formation in microorganisms, exhibits antibacterial and antifungal activities. Petroselinic acid is orally active[4.
    Petroselinic acid (Standard)
  • HY-155712
    Antifungal agent 70
    		Inhibitor
    Antifungal agent 70 (compound 13) is a dihydroeugenol-imidazole against multi-resistant Candida auris (MIC: 36.4 μM). Antifungal agent 70 shows antifungal activity.
    Antifungal agent 70
  • HY-126657
    Fumigaclavine A
    		Inhibitor
    Fumigaclavine A, a clavine alkaloid, is a Mycotoxin produced by Aspergillus fumigatus. A. fumigatus can be isolated from contaminating moldy silage.
    Fumigaclavine A
  • HY-P992076
    Anti-Candida auris β-1, 3 glucans Antibody (2G8)
    		Inhibitor
    Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms.The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Candida auris β-1, 3 glucans Antibody (2G8)
  • HY-N15738
    (-)-Zonarol
    		Inhibitor
    (-)-Zonarol is an antifungal agent. (-)-Zonarol exhibits divergent translational potential. (-)-Zonarol is an isomer of Zonarol. Zonarol is a (-)-Yahazunol-related natural product.
    (-)-Zonarol
  • HY-168204
    3-Acetyl-28-N-(3-guanidinobutoxy)-oleanolic acid
    		Inhibitor
    3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing.
    3-Acetyl-28-N-(3-guanidinobutoxy)-oleanolic acid
  • HY-170489
    Antifungal agent 123
    		Inhibitor
    Antifungal agent 123 (Compound 4b) exhibits good affinity to the oxidoreductase of Staphylococcus aureus or the membrane protein of Candida albicans, exhibits antibacterial and antifungal activities. Antifungal agent 123 scavenges free radical, exhibits antioxidant efficacy. Antifungal agent 123 inhibits the TLR signaling pathway, and exhibits anti-inflammatory efficacy.
    Antifungal agent 123
  • HY-W705791
    Metconazole-d6
    		Inhibitor
    Metconazole-d6 is the deuterium labeled Metconazole. Metconazole is a triazole fungicide agent.
    Metconazole-d<sub>6</sub>
  • HY-147919
    Antifungal agent 33
    		Inhibitor
    Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL.
    Antifungal agent 33
  • HY-N14937
    Albaflavenone
    		Inhibitor
    Albaflavenone is a sesquiterpene antibiotic with a zizaene skeleton. Albaflavenone is active against Bacillus subtilis.
    Albaflavenone
Cat. No. Product Name / Synonyms Application Reactivity