Anti-Candida auris β-1, 3 glucans Antibody (2G8) 

Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms^[1][2][3].The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Candida auris (C. auris)

Anti-Candida auris β-1,3-glucan Antibody (2G8) binds to β-1,3-glucan, inhibits fungal growth, interferes with capsule formation, exerts opsonizing effects, reduces fungal loads in mouse tissues, and exhibits comparable binding capacity to both encapsulated and non-encapsulated fungal strains^[1].
The anti-Candida auris β-1,3-glucan antibody (2G8) binds to the conserved N-linked glycoepitope on a specific acetylcholinesterase subtype, inhibits the activity of this specific acetylcholinesterase, and shows no cross-reactivity with butyrylcholinesterase^[2].
The anti-Candida auris β-1,3-glucan antibody (2G8) blocks the binding of TGF-β receptor, inhibits the Smad signaling pathway, reduces activated fibroblasts and collagen deposition, induces epithelial differentiation of tumor cells, and decreases pancreatic tumor metastasis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cryptococcus neoformans, β-D-glucan, Beta-D-Glucan, beta-Glucan, β-1, 3 glucans

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

[Anti-Candida auris β-1, 3 glucans Antibody (2G8)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rachini A, et al. An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo. Infect Immun. 2007;75(11):5085-5094.  [Content Brief]

  [2]. Liao J, et al. The monoclonal antibody 2G8 is carbohydrate‐specific and distinguishes between different forms of vertebrate cholinesterases[J]. European journal of biochemistry, 1991, 198(1): 59-65.

  [3]. Ostapoff KT, et al. Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res. 2014;74(18):4996-5007.  [Content Brief]