KFU-127 

KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells^[1]. KFU-127 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

KFU-127 (Compound 6b) shows antimycotic activity with MIC values of 0.38, 3.1, 3.1 and 3.1 μg/mL against Candida albicans, Trichophyton rubrum, Aspergillus fumigatus and Fusarium oxysporum, respectively^[1].
KFU-127 shows antibacterial activity with MIC values of 4, 4, 4 and 16 μg/mL against S. aureus ATCC 29213, B. subtilis 168, S. epidermidis and E. coli MG1655, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

607.62

C₃₄H₄₃BrN₂O₃

CCCC1OCC2=C(C(C[N+](C/C=C/C#CC(C)(C)C)(CC3=C4C=CC=CC4=CC=C3)C)=NC(C)=C2O1)CO.[Br-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Garipov MR, et al. Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile. Bioorg Chem. 2020 Nov;104:104306.  [Content Brief]