2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14248
    Melithiazole A
    		Inhibitor
    Melithiazol A is an antibiotic. Melithiazole A is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal and cytotoxic agent.
    Melithiazole A
  • HY-17395R
    Terbinafine hydrochloride (Standard)
    		Inhibitor
    Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine hydrochloride (Standard)
  • HY-N13999
    Clavamycin D
    		Inhibitor
    Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin D
  • HY-171795
    Isolubimin
    		Inhibitor
    Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.
    Isolubimin
  • HY-14282R
    Lanoconazole (Standard)
    		Inhibitor
    Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
    Lanoconazole (Standard)
  • HY-181101
    Antifungal agent 151
    		Inhibitor
    Antifungal agent 151 is a Prp8 intein inhibitor that inhibits the self-splicing process of the Prp8 intein, preventing maturation of the Prp8 protein. Antifungal agent 151 exerts in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 can be used for the research of cryptococcus pneumonia.
    Antifungal agent 151
  • HY-N12893
    Sclerodione
    		Inhibitor
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
    Sclerodione
  • HY-N14857
    Kanchanamycin C
    		Inhibitor
    Kanchanamycin C has anti-Gram positive and negative bacteria, yeast and filamentous fungus action.
    Kanchanamycin C
  • HY-B0537R
    Pentamidine (Standard)
    		Inhibitor
    Pentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine (Standard)
  • HY-182471
    Aminopyrifen
    		Inhibitor 98.85%
    Aminopyrifen is a GWT-1 inhibitor. Aminopyrifen inhibits the inositol acylation of phosphatidylinositol, disrupting the maturation process of GPI-anchored proteins and the integrity of fungal cell walls. Aminopyrifen strongly inhibits germ tube elongation of Botrytis cinerea, delays spore germination, prevents appressorium formation, and blocks the infection of plant tissues by pathogenic fungi. Aminopyrifen is effective against field populations of eggplant gray mold and cucumber powdery mildew, and can be used for research on various plant fungal diseases such as gray mold and powdery mildew.
    Aminopyrifen
  • HY-N14124
    Cladosporide D
    		Inhibitor
    Cladosporide D is found in the strain of Cladosporium sp. IFM 49191. Cladosporide D has no antifungal activity.
    Cladosporide D
  • HY-118578R
    Furalaxyl (Standard)
    		Inhibitor
    Furalaxyl (Standard) is the analytical standard of Furalaxyl. This product is intended for research and analytical applications. Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.
    Furalaxyl (Standard)
  • HY-138223
    6-Prenylindole
    		Inhibitor
    6-Prenylindole is an antifungal agent that can be isolated from Streptomyces.
    6-Prenylindole
  • HY-N14250
    Melithiazole C
    		Inhibitor
    Melithiazol C is an antibiotic. Melithiazole C is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal agent.
    Melithiazole C
  • HY-163633
    CYP51-IN-18
    		Inhibitor
    CYP51-IN-18 (compound 2l) is a potent CYP51 inhibitor with an IC50 of 0.219 μg/mL. CYP51-IN-18 shows significant fungicidal activity against B. cinerea with an EC50 of 0.369 μg/mL.
    CYP51-IN-18
  • HY-W015399R
    4-Methylcinnamic acid (Standard)
    		Inhibitor
    4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents.
    4-Methylcinnamic acid (Standard)
  • HY-118699
    Indole-3-thio carboxamide
    		Inhibitor 98.98%
    Indole-3-thio carboxamide is an antifungal agent. Indole-3-thio carboxamide is a biotransformation product of Camalexin (HY-119502) by plant pathogenic fungi Botrytis cinerea.
    Indole-3-thio carboxamide
  • HY-121214R
    Amisulbrom (Standard)
    		Inhibitor
    Amisulbrom (Standard) is the analytical standard of Amisulbrom (HY-121214). Amisulbrom is a fungicide. Amisulbrom can inhibit the cytochrome-bc1 complex of the mitochondrial electron and induce mitochondrial dysfunction. Amisulbrom can induce cell apoptosis, ROS production and cause G2/M phase arrest. Amisulbrom shows cardiovascular toxicity to zebrafish. Amisulbrom can be used for the researches of infection and cardiovascular disease.
    Amisulbrom (Standard)
  • HY-W572386
    2-n-Heptyl-4-quinolinol
    		Inhibitor
    2-n-Heptyl-4-quinolinol has activity against Candida albicans, Staphylococcus aureus, Vibrio anguillarum and V. Harveyi.
    2-n-Heptyl-4-quinolinol
  • HY-111264
    Naphthomycin B
    		Inhibitor
    Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis.
    Naphthomycin B
Cat. No. Product Name / Synonyms Application Reactivity