Antifungal agent 151

Antifungal agent 151 (compound B5) (1-64 μg/mL; 48 h) potently inhibits the growth of C. neoformans H99, C. gattii R265, fluconazole-resistant C. neoformans (strain 313), and clinical isolates of C. neoformans with MIC values ranging from 0.5 to 2 μg/mL^[1].
Antifungal agent 151 (compound B5) (8.0 μg/mL; until fungal elimination) exhibits rapid, concentration-dependent fungicidal activity against C. neoformans H99, eliminating the fungus within two hours^[1].
Antifungal agent 151 (compound B5) (2.0 μg/mL; 2 h) induces transcriptomic remodeling and inhibits proper intron splicing in C. neoformans H99, leading to oxidative stress, DNA damage responses, and altered metabolic gene expression^[1].
Antifungal agent 151 (compound B5) binds to the Prp8 intein active site via hydrogen bonds and a favorable distance for covalent interaction with Cys1^[1].
Antifungal agent 151 (compound B5) has IC₅₀ values of 14.99 μg/mL against LO2 cells and 10.31 μg/mL against A549 cells. Antifungal agent 151shows a lower MIC value against C. neoformans, conferring a higher therapeutic index than 6G-318S^[1].
Antifungal agent 151 (compound B5) (64 μg/mL) shows good blood compatibility with a 3.2% hemolysis rate at 64 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.