2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134635R
    Dehydrozingerone (Standard)
    		Inhibitor
    Dehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM.
    Dehydrozingerone (Standard)
  • HY-106546
    Tolciclate
    		Inhibitor
    Tolciclate (KC 9147) is an antifungal agent with in vitro inhibitory activity against dermatophytes, effective at concentrations of 0.01-0.1 μg/mL. Tolciclate is colorless and soluble in well-tolerated excipients, and it is more lipophilic than Tolnaftate (HY-B0370). Tolciclate can be used in research related to antifungal infections.
    Tolciclate
  • HY-N14814
    Neobulgarone F
    		Inhibitor
    Neobulgarone F is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone F can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone F
  • HY-N13024
    Radulone A
    		Inhibitor
    Radulone A is a secondary metabolite, which can be isolated from the wood decomposing fungus Granulobasidium vellereum. Radulone A inhibits spore germination of Phlebiopsis gigantea, Coniophora puteana and Heterobasidion occidentale, with concentrations of 10 µM, 500 µM and 100 µM, respectively.
    Radulone A
  • HY-126610
    Dactylfungin A
    		Inhibitor
    Dactylfungin A, an α-pyrone-containing antifungal agent found in Dactylaria parvispora.
    Dactylfungin A
  • HY-B2004R
    Thifluzamide (Standard)
    		Inhibitor
    Thifluzamide (Standard) is the analytical standard of Thifluzamide. This product is intended for research and analytical applications. Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants.
    Thifluzamide (Standard)
  • HY-136754
    CYP51-IN-4
    		Inhibitor
    CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-4
  • HY-N14409
    Mycoversilin
    		Inhibitor
    Mycoversilin is an antibiotic. Mycoversilin has the activity of inhibiting skin fungi and phytopathogenic fungi, but has no anti-yeast and bacterial activity. Mycoversilin has a strong inhibitory effect on protein synthesis.
    Mycoversilin
  • HY-B2008R
    Famoxadone (Standard)
    		Inhibitor
    Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases.
    Famoxadone (Standard)
  • HY-N15057
    Chivosazol A
    		Inhibitor
    Chivosazol A has anti-yeast and filamentous fungal activity and has strong toxicity to mammalian cells.
    Chivosazol A
  • HY-N14878
    Enactin Ⅰb
    		Inhibitor
    Enactin Ib is found in the strain of Streptomyces roseoviridis. Enactin Ib has only weak antifungal activity.
    Enactin Ⅰb
  • HY-N14018
    Glidobactin A
    		Inhibitor
    Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candida albicans M-9 infection in mice.
    Glidobactin A
  • HY-17395AS1
    Terbinafine-d3
    		Inhibitor
    Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine-d<sub>3</sub>
  • HY-183722
    SDH-IN-46
    		Inhibitor
    SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.
    SDH-IN-46
  • HY-N15375
    Trichomycin B
    		Inhibitor
    Trichomycin B is a polyene macrolide antibiotic that can be isolated from the fermentation products of Streptomyces hachijoensis. Trichomycin B exhibits antibacterial activity against fungi, yeasts, and trichomonas. Trichomycin B can be used in research on antifungal and anti-trichomoniasis infection.
    Trichomycin B
  • HY-119726A
    Fosmanogepix (tautomerism)
    		Inhibitor
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections.
    Fosmanogepix (tautomerism)
  • HY-N11407
    Bagougeramine B
    		Inhibitor
    Bagougeramine B is an orally active nucleoside antibiotic with antimicrobial activity, which is found in Bacillus circulans. Bagougeramine B inhibits the growth of Gram-positive and Gram-negative bacteria and some fungi.
    Bagougeramine B
  • HY-N14158
    Epelmycin D
    		Inhibitor
    Epelmycin D has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin D
  • HY-W716339
    (+)-β-Pinene
    		Inhibitor
    (+)-β-Pinene is an enantiomer of a (-)-β-pinene. (+)-β-pinene has antifungal activity and most likely acts through interference with the cell wall;
    (+)-β-Pinene
  • HY-B2058R
    Triticonazole (Standard)
    		Inhibitor
    Triticonazole (Standard) is the analytical standard of Triticonazole. This product is intended for research and analytical applications. Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities.
    Triticonazole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity