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Cat. No.: HY-119726A

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Fosmanogepix (tautomerism)

(Synonyms: APX001 (tautomerism); E1211 (tautomerism))

Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections.

For research use only. We do not sell to patients.

CAS No.: 1169701-00-1
Formula: C₂₂H₂₁N₄O₆P
Molecular Weight:468.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Fosmanogepix (tautomerism) Chemical Structure

CAS No.: 1169701-00-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 1169701-00-1
Molecular Weight 468.40
Formula C₂₂H₂₁N₄O₆P
SMILES

N=C1C(C2=CC(CC3=CC=C(C=C3)COC4=NC=CC=C4)=NO2)=CC=CN1COP(O)(O)=O
Synonyms

APX001 (tautomerism); E1211 (tautomerism)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gebremariam, et al. "APX001 is effective in the treatment of murine invasive pulmonary aspergillosis." Antimicrobial agents and chemotherapy 63.2 (2019): 10-1128. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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