2. Anti-infection
  3. Fungal
  4. Fosmanogepix

Fosmanogepix  (Synonyms: APX001; E1211)

Cat. No.: HY-119726 Purity: ≥97.0%
COA Handling Instructions

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections.

For research use only. We do not sell to patients.

Fosmanogepix Chemical Structure

Fosmanogepix Chemical Structure

CAS No. : 2091769-17-2

Size Price Stock Quantity
5 mg USD 580 In-stock
10 mg USD 850 In-stock
50 mg USD 1900 In-stock
100 mg USD 2800 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections[1][2].

IC50 & Target

Gwt1[1]
Clinical Trial
Molecular Weight

468.40

Appearance

Solid

Formula

C22H21N4O6P
CAS No.
SMILES

O=P(OC[N]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O].[+].[-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.67 mM; ultrasonic and adjust pH to 4 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1349 mL 10.6746 mL 21.3493 mL
5 mM 0.4270 mL 2.1349 mL 4.2699 mL
10 mM 0.2135 mL 1.0675 mL 2.1349 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥97.0%

COA (249 KB) HNMR (276 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fosmanogepix2091769-17-2APX001 E1211APX 001APX-001E1211E 1211E-1211FungalInhibitorinhibitorinhibit

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