1. Anti-infection
  2. Fungal
  3. Fosmanogepix

Fosmanogepix (Synonyms: APX001; E1211)

Cat. No.: HY-119726
Handling Instructions

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections.

For research use only. We do not sell to patients.

Fosmanogepix Chemical Structure

Fosmanogepix Chemical Structure

CAS No. : 2091769-17-2

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Description

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections[1][2].

IC50 & Target

Gwt1[1]

Molecular Weight

468.40

Formula

C₂₂H₂₁N₄O₆P

CAS No.

2091769-17-2

SMILES

O=P(OC[N]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O].[+].[-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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