2091769-17-2
Chemical Structure
Fosmanogepix
Synonym(s): APX001; E1211
- CAS No.: 2091769-17-2
- Formula:C22H21N4O6P
- Molecular Weight:468.40
IUPAC Name: (2-amino-3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-1-ium-1-yl)methyl hydrogen phosphate
InChIKey: JQONJQKKVAHONF-UHFFFAOYSA-N
SMILES: O=P(OC[N+]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O-]
Biological Activity: Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fosmanogepix | 99.26% | Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research. | ||||||||||||||||||||
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Keywords
