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Cat. No.: HY-183722

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SDH-IN-46

SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.

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화학식: C₁₈H₁₃F₅N₄O
분자량:396.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDH-IN-46 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

SDH-IN-46 (Compound 6i) (20 μg/mL) inhibits mycelial growth of Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Fusarium graminearum, and Botrytis cinerea by 66.2-92.4%^[1].
SDH-IN-46 potently inhibits mycelial growth of Sclerotinia sclerotiorum with an EC₅₀ of 0.44 μg/mL, and inhibits Rhizoctonia solani, Valsa mali, Fusarium graminearum, and Botrytis cinerea with EC₅₀ values ranging from 1.05-5.41 μg/mL^[1].
SDH-IN-46 potently inhibits Sclerotinia sclerotiorum succinate dehydrogenase with an IC₅₀ of 1.21 μM^[1].
SDH-IN-46 (1 μg/mL) causes significant structural damage to Sclerotinia sclerotiorum hyphae, including wrinkling, shrinkage, and rupture^[1].
SDH-IN-46 (100 μg/mL) shows protective efficacy against S. sclerotiorum on oilseed rape leaves, R. solani on rice leaves, and V. mali on apple fruits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 396.31
화학식 C₁₈H₁₃F₅N₄O
SMILES

O=C(NC1=CN(C)N=C1C(F)F)C2=CC=CC=C2NC3=CC(F)=C(F)C(F)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Luo B, et al. Design and Synthesis of Novel N-(Pyrazol-4-yl)benzamide Derivatives Featuring a Diphenylamine or Diphenyl Ether Scaffold as Potential Broad-Spectrum SDH Inhibitors. J Agric Food Chem. 2026;74(18):14263-14274. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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