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Cat. No.: HY-183722

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SDH-IN-46

SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₃F₅N₄O
Molecular Weight:396.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDH-IN-46 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

SDH-IN-46 (Compound 6i) (20 μg/mL) inhibits mycelial growth of Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Fusarium graminearum, and Botrytis cinerea by 66.2-92.4%^[1].
SDH-IN-46 potently inhibits mycelial growth of Sclerotinia sclerotiorum with an EC₅₀ of 0.44 μg/mL, and inhibits Rhizoctonia solani, Valsa mali, Fusarium graminearum, and Botrytis cinerea with EC₅₀ values ranging from 1.05-5.41 μg/mL^[1].
SDH-IN-46 potently inhibits Sclerotinia sclerotiorum succinate dehydrogenase with an IC₅₀ of 1.21 μM^[1].
SDH-IN-46 (1 μg/mL) causes significant structural damage to Sclerotinia sclerotiorum hyphae, including wrinkling, shrinkage, and rupture^[1].
SDH-IN-46 (100 μg/mL) shows protective efficacy against S. sclerotiorum on oilseed rape leaves, R. solani on rice leaves, and V. mali on apple fruits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 396.31
Formula C₁₈H₁₃F₅N₄O
SMILES

O=C(NC1=CN(C)N=C1C(F)F)C2=CC=CC=C2NC3=CC(F)=C(F)C(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Luo B, et al. Design and Synthesis of Novel N-(Pyrazol-4-yl)benzamide Derivatives Featuring a Diphenylamine or Diphenyl Ether Scaffold as Potential Broad-Spectrum SDH Inhibitors. J Agric Food Chem. 2026;74(18):14263-14274. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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