SDH-IN-46 

SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits^[1].

SDH-IN-46 (Compound 6i) (20 μg/mL) inhibits mycelial growth of Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Fusarium graminearum, and Botrytis cinerea by 66.2-92.4%^[1].
SDH-IN-46 potently inhibits mycelial growth of Sclerotinia sclerotiorum with an EC₅₀ of 0.44 μg/mL, and inhibits Rhizoctonia solani, Valsa mali, Fusarium graminearum, and Botrytis cinerea with EC₅₀ values ranging from 1.05-5.41 μg/mL^[1].
SDH-IN-46 potently inhibits Sclerotinia sclerotiorum succinate dehydrogenase with an IC₅₀ of 1.21 μM^[1].
SDH-IN-46 (1 μg/mL) causes significant structural damage to Sclerotinia sclerotiorum hyphae, including wrinkling, shrinkage, and rupture^[1].
SDH-IN-46 (100 μg/mL) shows protective efficacy against S. sclerotiorum on oilseed rape leaves, R. solani on rice leaves, and V. mali on apple fruits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.31

C₁₈H₁₃F₅N₄O

O=C(NC1=CN(C)N=C1C(F)F)C2=CC=CC=C2NC3=CC(F)=C(F)C(F)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo B, et al. Design and Synthesis of Novel N-(Pyrazol-4-yl)benzamide Derivatives Featuring a Diphenylamine or Diphenyl Ether Scaffold as Potential Broad-Spectrum SDH Inhibitors. J Agric Food Chem. 2026;74(18):14263-14274.