2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136425R
    Fosetyl-aluminum (Standard)
    		Inhibitor
    Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum (Standard)
  • HY-N3056R
    Pinosylvin monomethyl ether (Standard)
    Pinosylvin monomethyl ether (Standard) is the analytical standard of Pinosylvin monomethyl ether. This product is intended for research and analytical applications. Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.
    Pinosylvin monomethyl ether (Standard)
  • HY-N14956
    Fulvoferruginin
    		Inhibitor
    Fulvoferruginin showed cytotoxicity and antifungal activity, especially to Paecilomyces varioti.
    Fulvoferruginin
  • HY-N14192
    Maltophilin
    		Inhibitor
    Maltophilin is a broad-spectrum antifungal antibiotic that has no antibacterial effect against Gram-positive and Gram-negative bacteria.
    Maltophilin
  • HY-168396
    Glioroseinol
    Glioroseinol is a fungal metabolite that can be found in Gliocladium, and is a derivative of Gliorosein (HY-N10228).
    Glioroseinol
  • HY-122480
    Fenaminstrobin
    		Inhibitor
    Fenaminstrobin (SYP-1620) is a strobilurin Fungicide. Fenaminstrobin binds to cytochrome bc1 in the mitochondrial respiratory chain, thereby inhibiting ATP production. Fenaminstrobin exhibits acute toxicity to Daphnia magna. Fenaminstrobin effectively controls diseases such as Fusarium ear rot, downy mildew, rice blast and pear scab.
    Fenaminstrobin
  • HY-N15091
    Formamicin
    		Inhibitor
    Formamicin has broad spectrum and strong anti-plant pathogenic fungi activity.
    Formamicin
  • HY-N3006R
    Sakuranetin (Standard)
    		Inhibitor
    Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
    Sakuranetin (Standard)
  • HY-123096
    Silthiofam
    Silthiofam (Silthiopham) is a wheat fungicide used to control take-all disease caused by the soil-borne fungus Gaeumannomyces graminis.
    Silthiofam
  • HY-N14441
    Haliangicin A
    		Inhibitor
    Haliangicin A has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin A
  • HY-B0852S2
    Tebuconazole-d6
    Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
    Tebuconazole-d<sub>6</sub>
  • HY-N17348
    5,6,7,8-Tetramethoxyflavone
    		Inhibitor
    5,6,7,8-Tetramethoxyflavone is a flavonoid with antifungal and antibacterial activities, capable of inhibiting the growth of *Staphylococcus aureus* and *Candida albicans*. 5,6,7,8-Tetramethoxyflavone can be utilized in research related to infections [1].
    5,6,7,8-Tetramethoxyflavone
  • HY-N6805A
    (E)-Isoeugenol acetate
    		Inhibitor
    (E)-Isoeugenol acetate, a Eugenol derivative, possesses antifungal activity.
    (E)-Isoeugenol acetate
  • HY-N6013R
    Aloin (mixture of A&B) (Standard)
    		Inhibitor
    Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma.
    Aloin (mixture of A&B) (Standard)
  • HY-178108
    Anti-MRSA agent 35
    		Inhibitor
    Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC50s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .
    Anti-MRSA agent 35
  • HY-W744966R
    Mandipropamid (Standard)
    		Inhibitor
    Mandipropamid (Standard) is the analytical standard of Mandipropamid. This product is intended for research and analytical applications. Mandipropamid displays outstanding activity against late blight diseases of potato and tomato, combined with excellent efficacy on downy mildew diseases of grape and cucumber.
    Mandipropamid (Standard)
  • HY-N15110
    Phosmidosine
    		Inhibitor
    Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.
    Phosmidosine
  • HY-162488
    Laccase-IN-3
    		Inhibitor
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
    Laccase-IN-3
  • HY-W714655
    Becliconazole
    		Inhibitor
    Becliconazole is a fungal CYP51A1 inhibitor. Becliconazole can be used in research on fungal infections.
    Becliconazole
  • HY-178162
    CYP51-IN-27
    		Inhibitor
    CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC50 of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight.
    CYP51-IN-27
Cat. No. Product Name / Synonyms Application Reactivity