Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2720)
Related Products (2720)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Iprobenfos (Standard)
0 ImagesCat. No.: HY-B1863RCAS No.: 26087-47-8Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
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Fenticonazole Nitrate (Standard)
0 ImagesSynonyms: REC 15-1476 (Standard)Fenticonazole (Nitrate) (Standard) is the analytical standard of Fenticonazole (Nitrate). This product is intended for research and analytical applications. Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis.
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CYP51-IN-33
0 ImagesCat. No.: HY-187437CAS No.: 3133348-60-1CYP51-IN-33 is a CYP51 inhibitor with an IC50 of 0.35 μM against the sterol 14α-demethylase activity of Rhizoctonia solani CYP51. CYP51-IN-33 interferes with CYP51-associated ergosterol biosynthesis, accompanied by changes in hyphal morphology, increased membrane permeability and intracellular ROS accumulation. CYP51-IN-33 can be used in studies on CYP51-targeted antifungal activity and rice sheath blight.
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Galbonolides A
0 ImagesCat. No.: HY-N14984CAS No.: 100157-26-4Galbonolides A exhibits biological activity against a broad spectrum of fungi.
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trans-2-Hexenal-d2-1
0 ImagesCat. No.: HY-128429SCAS No.: 164791-70-2Synonyms: (E)-2-Hexenal-d2-1trans-2-Hexenal-d2-1 is the deuterium labeled trans-2-Hexenal (HY-128429). trans-2-Hexenal ((E)-2-Hexenal) is a volatile compound widely present in fresh plants, vegetables, and fruits, with a unique leafy aroma. trans-2-Hexenal has antifungal activity and can also inhibit the germination of soybean seeds and the growth of seedlings. In addition, trans-2-Hexenal can be used to determine low-molecular-weight carbonyl compounds that are reactive with biological nucleophiles in biological samples.
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Cuevaene B
0 ImagesCat. No.: HY-N14112CAS No.: 274684-11-6Cuevaene B can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene B displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
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Lupeol acetate (Standard)
0 ImagesCat. No.: HY-126114RCAS No.: 1617-68-1Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.
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Guaiazulene (Standard)
0 ImagesGuaiazulene (Standard) is the analytical standard of Guaiazulene (HY-N6951). This product is intended for research and analytical applications. Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations.
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5-Geranoxy-7-methoxycoumarin
0 Images5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and ?antibacterial?activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis.
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Ossamycin
0 ImagesCat. No.: HY-N14853CAS No.: 2057463-74-6Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively.
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Fusacandin B
0 ImagesCat. No.: HY-N14472CAS No.: 166407-34-7Fusacandin B inhibits (1,3)-β-glucan synthetase and has antifungal properties.
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2-Methoxybenzaldehyde (Standard)
0 Images2-Methoxybenzaldehyde (Standard) is the analytical standard of 2-Methoxybenzaldehyde. This product is intended for research and analytical applications. 2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases.
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Cladosporide C
0 ImagesCat. No.: HY-N14123CAS No.: 376368-82-0Cladosporide C is found in the strain of Cladosporium sp. IFM 49190. Cladosporide C has no antifungal activity.
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(+)-Tuberine
0 ImagesCat. No.: HY-187580CAS No.: 97400-75-4(+)-Tuberine is an alkaloid found in Haplophyllum tuberculatum, with antibacterial and antifungal activities. (+)-Tuberine can be used in studies on antimicrobial natural products and microbial growth inhibition.
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Phaseollidin
0 ImagesCat. No.: HY-N3089CAS No.: 37831-70-2Phaseollidin is an antifungal agent that can be isolated from Phaseolus vulgaris L..
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Dihydroniphimycin
0 ImagesCat. No.: HY-N14554CAS No.: 157536-03-3Dihydroniphimycin has anti-fungal, yeast and Gram-positive bacteria action.
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Poly diallyldimethylammonium chloride
0 ImagesCat. No.: HY-W110755CAS No.: 26062-79-3Poly diallyldimethylammonium chloride is a cationic polymer with quaternary ammonium side groups, which exhibits excellent flocculation performance and thermal stability. Poly diallyldimethylammonium chloride also possesses microbicidal activity. Poly diallyldimethylammonium chloride can be used in studies on bacterial and fungal infections, as well as in research related to water treatment, textile printing and dyeing, papermaking chemical industry and other fields, with a wide range of applications.
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Diniconazole (Standard)
0 ImagesSynonyms: S 3308 (Standard)Diniconazole (Standard) is the analytical standard of Diniconazole (HY-B1948). This product is intended for research and analytical applications. Diniconazole (S-3308) is a newly developed fungicide. Diniconazole exhibits fungicidal activity against Bolrytis cintrca, Sordaria fumicola, Fusarium graminearum, Sclerotium cepivornm, and Bipolaris sorokiniana with IC50 values of 0.012, <0.001, 0.008, 0.02, and 0.06 mg/L, respectively. Diniconazole can be used in research related to the prevention and control of plant fungal diseases and plant growth regulation.
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RK-286D
0 ImagesCat. No.: HY-116060CAS No.: 140429-37-4RK-286D is an antibiotic and a PKC inhibitor with antimicrobial activity. RK-286D shows inhibitory activities against bleb formation induced by PDBu (HY-18985) and in vitro PKC activity.
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Episterol
0 ImagesEpisterol is an Ergosterol (HY-N0181) biosynthetic intermediate. Episterol replaces Ergosterol as the major sterol in Saccharomyces cerevisiae Δerg3 mutants, confers resistance to combined lethal and vacuole-disruptive actions of Amphotericin B (HY-B0221) and MC12 (HY-175024).
