Laccase-IN-3
Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
For research use only. We do not sell to patients.
- Formula: C14H15FN2O
- Molecular Weight:246.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Laccase-IN-3 (25 mg/L) inhibitis the fungal activity by is 98.2% (B. dothidea), 92% (S. sclerotiorum), 93.9 % (F. graminearum), 53.1 % (B. cinerea), 59.9 % (P. capsici), 22.0 % (P. infestans), 81.5 % (P. nicotianae), respectively[1].
Laccase-IN-3 shows ECsub>50 against various fungi: 0.17 mg/L (B. dothidea), 2.55 mg/L (S. sclerotiorum), 2.03 mg/L (F. graminearum)[1].
Laccase-IN-3 (0.79-6.25 mg/L;) inhibits fungal growth by disrupting the morphology of B. dothidea[1].
Laccase-IN-3 (10-25 mg/L; 120min) disrupts cell membrane integrity and increases cell membrane permeability of B. dothidea mycelia. Laccase-IN-3 reduces the extracellular pH and destabilizes the intracellular environment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 246.28
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Formula C14H15FN2O
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SMILES
O=C([C@H]1[C@H](C2)C=C[C@H]2C1)NNC3=CC=C(F)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laccase-IN-3 Related Classifications
HY-162488 Related Classifications
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