2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N16519
    [6]-Gingerdiol
    		Inhibitor
    [6]-Gingerdiol is an antifungal agent. [6]-Gingerdiol can be isolated from Zingiber officinale. [6]-Gingerdiol shows antifungal activity against M. gypseum with a MLC value of 422 μg/mL.
    [6]-Gingerdiol
  • HY-138229
    1β-Acetoxypolygodial
    		Inhibitor
    1β-Acetoxypolygodial is a sesquiterpenoid found in Tasmannia lanceolata. 1β-Acetoxypolygodial is promising for research of cancers and fungal infections.
    1β-Acetoxypolygodial
  • HY-N1944S
    Nerolidol-d4
    		Inhibitor
    Nerolidol-d4 is deuterated labeled Nerolidol (HY-N1944). Nerolidol has multiple natural membrane activities, possesses anti-cancer, anti-inflammatory, antibacterial and anti-insect activity. Nerolidol Suppresses parasitic activity, suppresses bloodsucking diseases, bloodworm diseases, and other diseases. Nerolidol can protect the cells from lipid and protein properties, damage to DNA, and protect the cells from damage.
    Nerolidol-d<sub>4</sub>
  • HY-118216
    Bitertanol
    		Inhibitor 98.70%
    Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro.
    Bitertanol
  • HY-155703
    LW3
    		Inhibitor 99.87%
    LW3 is a potent antifungal agent. LW3 has antifungal activity with EC50 values of 0.54, 0.09, 1.52, and 2.65 mg/L against B. cinerea, R. solani, S. sclerotiorum, and F. graminearum, respectively.
    LW3
  • HY-177881
    Savirin
    		Inhibitor
    Savirin exhibits in vitro antibacterial and antibiofilm activity. Savirin can prevent skin infections induced by S. aureus in vivo. Savirin shows enhanced activity when combined with antibiotics.
    Savirin
  • HY-W740833
    Iodopropynyl butylcarbamate-d9
    Iodopropynyl butylcarbamate-d9 (IPBC-d9) is the deuterium labeled Iodopropynyl butylcarbamate (HY-W009335). Iodopropynyl butylcarbamate (IPBC) is a potent fungicide and preservative, which has been used in the paints, coatings, wood preservatives, personal care, and cosmetics industries.
    Iodopropynyl butylcarbamate-d<sub>9</sub>
  • HY-155769
    Antimicrobial agent-24
    		Inhibitor
    Antimicrobial agent-24 (compound E8) is a hydrazide compound with excellent and broad-spectrum fungicidal activities. Antimicrobial agent-24 affects the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia.
    Antimicrobial agent-24
  • HY-105476
    TAN 950A
    		Inhibitor
    TAN 950A is antifungal amino acid antibiotic. TAN 950A has affinity for three excitatory amino acid (EAA) receptor and can inhibit [3H]AMPA, [3H]kainite and [3H]CPP binding competitively. TAN 950A can be used for the researches of infection and neurological disease.
    TAN 950A
  • HY-W142410
    2-Dodecanol
    2-Dodecanol inhibits hyphal formation and SIR2 expression in C. albicans.
    2-Dodecanol
  • HY-183308
    Antifungal agent-161
    		Inhibitor
    Antifungal agent-161 (Compound 7) is an Antifungal agent. Antifungal agent-161 potently inhibits Candida albicans ATCC 36082 (with a MIC of 1.32 μM) and Candida glabrata ATCC 2001 (with a MIC of 1.66 μM). Antifungal agent-161 reduces fungal loads in infected mice and eliminates Candida albicans and Candida glabrata infections. Antifungal agent-161 can be used for the research of candidiasis.
    Antifungal agent-161
  • HY-N18069
    Avenanthramide L
    		Inhibitor
    Avenanthramide L is a phytoalexin that can inhibit the spore germination of Puccinia coronata f. sp. avenae. Avenanthramide L is found in the leaves of inoculated oats, but not in the leaves of healthy oat seedlings, and at a concentration of 200-300 μg/mL. Avenanthramide L inhibits fungal spore germination by up to 50%. Avenanthramide L is absent from the leaves of healthy oat seedlings. Avenanthramide L can be used for the research of oat crown rust.
    Avenanthramide L
  • HY-N10272
    (±)-Avenaciolide
    		Inhibitor
    Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation.
    (±)-Avenaciolide
  • HY-B1729S1
    Phenoxyethanol-d4
    		Inhibitor
    Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol-d<sub>4</sub>
  • HY-130047
    Bivittoside A
    Bivittoside A is a non-sulfated hexoside analog derived from Bovine sea cucumber, exhibiting antifungal properties and potential for antitumor applications.
    Bivittoside A
  • HY-Y0319D
    Acetic acid lead
    		Inhibitor
    Acetic acid lead is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Acetic acid lead exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Acetic acid lead regulates energy metabolism. Acetic acid lead has anticancer activity against gastric cancer. Acetic acid lead induces writhing reaction and ulcerative colitis. Acetic acid lead can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain.
    Acetic acid lead
  • HY-17583S1
    Griseofulvin-13C,d3
    		Inhibitor
    Griseofulvin-13C,d3 is the 13C- and deuterium labeled Griseofulvin.
    Griseofulvin-<sup>13</sup>C,d<sub>3</sub>
  • HY-156151
    CYP51/PD-L1-IN-3
    		Inhibitor
    CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
    CYP51/PD-L1-IN-3
  • HY-W705792
    Ethaboxam-d5
    Ethaboxam-d5 (Intego solo-d5) is the deuterium labeled Ethaboxam (HY-107492). Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam-d<sub>5</sub>
  • HY-152909
    Nystatin A2
    		Inhibitor
    Nystatin A2 is an active component of antifungal agent, Nystatin (HY-17409). Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma.
    Nystatin A2
Cat. No. Product Name / Synonyms Application Reactivity