CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
For research use only. We do not sell to patients.
- CAS No.: 3032386-59-4
- Formula: C27H28N6O2
- Molecular Weight:468.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.205 μM (CYP51), 0.039 μM (PD-L1)[1]
Chemical Information
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CAS No. 3032386-59-4
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Molecular Weight 468.55
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Formula C27H28N6O2
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SMILES
O=C(C1=NC2=CC=CC=C2C(N3C=NC=C3)=N1)NC4CCN(C(C5=CC=C(C(C)C)C=C5)=O)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP51/PD-L1-IN-3 Related Classifications
HY-156151 Related Classifications
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