3032386-59-4
Chemical Structure
CYP51/PD-L1-IN-3
- CAS No.: 3032386-59-4
- Formula:C27H28N6O2
- Molecular Weight:468.55
InChIKey: QUXRRYSRXWYLPU-UHFFFAOYSA-N
SMILES: O=C(C1=NC2=CC=CC=C2C(N3C=NC=C3)=N1)NC4CCN(C(C5=CC=C(C(C)C)C=C5)=O)CC4
Biological Activity: CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].
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CYP51/PD-L1-IN-3 | CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death. | |||||||||||||||||||||
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Keywords
