Acetic acid lead
Acetic acid lead is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Acetic acid lead exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Acetic acid lead regulates energy metabolism. Acetic acid lead has anticancer activity against gastric cancer. Acetic acid lead induces writhing reaction and ulcerative colitis. Acetic acid lead can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain.
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- CAS. Nr.: 546-67-8
- Formel: C2H4O2.1/4Pb
- Molecular Weight:447.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Acetic acid lead (Acetic acid; 2-5 µM; 24 h) induces cancer cell-selective death in gastric cancer cells (RGK1) via oxidative stress, while having minor effects on normal gastric mucosal cells (RGM1)[3].
Acetic acid lead (Acetic acid; 20-200 mM; 200 min) induces programmed cell death in Saccharomyces cerevisiae W303-1A[4].
Acetic acid lead (Acetic acid; 5 mM; 15 d) suppresses the increase in disaccharidase activity (sucrase, maltase, trehalase, lactase) in Caco-2 cells without affecting cell growth or glucose transport[5].
Acetic acid lead (Acetic acid; 8-7.2 mM; 3 h) activates the AMPKα signaling pathway by consuming ATP to increase the AMP/ATP ratio in bovine hepatocytes, upregulating lipid oxidation genes, downregulating lipogenic genes, and reducing intracellular triglyceride content[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat gastric mucosal cells (RGM1), cancerous gastric mucosal cells (RGK1)
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Concentration:0, 1, 2, 5, 10, 20 µM
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Incubation Time:24 h
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Result:Increased monocarboxylic transporter 1 (MCT1) and cleaved caspase 9 in RGK1 cells.
Showed minor effects in RGM1 cells.
In Vivo
Acetic acid lead (5% v/v; i.r.; single dose) induces severe ulcerative colitis in male Kunming mice, characterized by high mortality, increased disease activity index, colon tissue damage, elevated neutrophil infiltration, and upregulated pro-inflammatory cytokine and NF-κB p65 expression[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 20-33g)[7]
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Dosage:0.10%; 0.18%; 0.32%; 0.56%
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Administration:i.p.; single dose
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Result:Reduced Ensure consumption to 0.09 g/g body weight at 0.32% dose, significantly lower than control 0.14 g/g body weight.
Reduced Ensure consumption to 0.03 g/g body weight at 0.56% dose, significantly lower than control 0.14 g/g body weight.
Induced a mean of approximately 32 writhes over 20 minutes at 0.56% dose.
Produced significant feeding-suppressant effects at 0 and 60 minutes post-administration with 0.56% dose, which were no longer apparent by 240 minutes post-administration.
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Animal Model:Kunming mice (male, 20-25 g)[8]
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Dosage:5% v/v
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Administration:i.r.; single dose
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Result:Caused severe colitis with bloody diarrhea, poor coat quality, dramatic body weight loss, reduced mobility, and gross blood adhesion to the anus.
Resulted in a high mortality rate.
Led to 78.44% colon area affected.
Caused wet colon weight/length of 162.8 mg/cm.
Resulted in a macroscopic score of ~3.8.
Induced a histological score of ~3.9.
Increased colonic MPO activity to ~2.4 U/g tissue.
Elevated serum and colonic TNF-α and IL-6.
Distinctly elevated p65 NF-κB protein expression compared to normal controls.
Chemical Information
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CAS. Nr. 546-67-8
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Molecular Weight 447.43
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Formel C2H4O2.1/4Pb
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SMILES
CC([O-])=O.[0.25Pb4+]
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Syka JE, et al. Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9528-33. [Content Brief]
[3]. Terasaki M, et al. Acetic acid is an oxidative stressor in gastric cancer cells. J Clin Biochem Nutr. 2018 Jul;63(1):36-41. [Content Brief]
[4]. Ludovico P, et al. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology (Reading). 2001 Sep;147(Pt 9):2409-2415. [Content Brief]
[5]. Ogawa N, et al. Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco-2 cells. J Nutr. 2000 Mar;130(3):507-13. [Content Brief]
[6]. Li X, et al. Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. PLoS One. 2013 Jul 4;8(7):e67880. [Content Brief]
[7]. Stevenson GW, et al. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain. 2006 Jun;7(6):408-16. [Content Brief]
[8]. Niu X, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. [Content Brief]
[9]. Granado-Serrano AB, et al. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia. Sci Rep. 2019 Feb 11;9(1):1772. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Acetic acid lead Related Classifications
HY-Y0319D Related Classifications
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