2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N6625S
    Chlorothalonil-13C2
    		Inhibitor
    Chlorothalonil-13C2 is the 13C-labeled Chlorothalonil. Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops.
    Chlorothalonil-<sup>13</sup>C<sub>2</sub>
  • HY-129515
    Trichodecenin II
    Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride.
    Trichodecenin II
  • HY-17396S
    Butenafine-13C,d3 hydrochloride
    		Inhibitor
    Butenafine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
    Butenafine-<sup>13</sup>C,d<sub>3</sub> hydrochloride
  • HY-121178
    Deoxyviolacein
    		Inhibitor
    Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.
    Deoxyviolacein
  • HY-77995S
    2-Methoxybenzaldehyde-d3
    2-Methoxybenzaldehyde-d3 is the deuterium labeled 2-Methoxybenzaldehyde. 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity.
    2-Methoxybenzaldehyde-d<sub>3</sub>
  • HY-N13197
    6-Methyl-5,6-dihydro-2H-pyran-2-one
    		Inhibitor
    6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities.
    6-Methyl-5,6-dihydro-2H-pyran-2-one
  • HY-147804
    SARS-CoV-2 3CLpro-IN-3
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-3 (Compound 3d) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
    SARS-CoV-2 3CLpro-IN-3
  • HY-B1729S
    Phenoxyethanol-d2
    		Inhibitor
    Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol-d<sub>2</sub>
  • HY-N8256
    (–)-Mycousnine
    		Inhibitor
    (–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).
    (–)-Mycousnine
  • HY-137356
    Prochloraz manganese
    		Inhibitor
    Prochloraz manganese is an antifungal agent, and is used in agricultural industries.
    Prochloraz manganese
  • HY-N6687A
    Calcimycin hemicalcium salt
    		Inhibitor
    Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy.
    Calcimycin hemicalcium salt
  • HY-P10513
    AcrAP1
    		Inhibitor
    AcrAP1 (AP1-Z1) is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP1 has antimicrobial activity and can inhibit the growth of Gram-positive and Gram-negative bacteria as well as yeast. AcrAP1 exerts antitumor activity by promoting apoptosis of cancer cells and inhibiting angiogenesis. AcrAP1 can be used in cancer therapy research.
    AcrAP1
  • HY-129728
    Lienomycin
    		Inhibitor
    Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity.
    Lienomycin
  • HY-106542
    Eberconazole
    Eberconazole is a dichlorinated imidazole derivative with antifungal activity. Eberconazole is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole has potential for the study of dermatophytosis.
    Eberconazole
  • HY-B0849S1
    Azoxystrobin-d3
    		Inhibitor
    Azoxystrobin-d3 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin-d<sub>3</sub>
  • HY-172222
    Antifungal agent 127
    		Inhibitor
    Antifungal agent 127 (Compound 6c) is an antifungal agent. Antifungal agent 127 exhibits strong inhibitory activity against Botrytis cinerea, Rhizoctonia solani, and other fungi.
    Antifungal agent 127
  • HY-W150903S
    N-Heptyl 4-hydroxybenzoate-d4
    		Inhibitor
    N-Heptyl 4-hydroxybenzoate-d4 is the deuterium labeled N-Heptyl 4-hydroxybenzoate (HY-W150903). N-Heptyl 4-hydroxybenzoate (p-Oxybenzoesaureheptylester) is an antimicrobial agent that inhibits S. aureus with MIC of 12.5 μg/mL. N-Heptyl 4-hydroxybenzoate also against plant pathogenic fungi, such as Alternaria brassicicola, F. solani, C. dematium and C. acutatum.
    N-Heptyl 4-hydroxybenzoate-d<sub>4</sub>
  • HY-W743674
    Difenoconazole-d6
    Difenoconazole-d6 is the deuterium labeled Difenoconazole (HY-B0850). Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole-d<sub>6</sub>
  • HY-126167
    Deacetylsclerotiorin
    		Inhibitor
    Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM).
    Deacetylsclerotiorin
  • HY-N1130
    Trianthenol
    		Inhibitor
    Trianthenol is a tetraterpenoid antifungal agent that can be extracted from the whole plant of Trianthema portulacastrum (a plant of the genus Trianthema in the Aizoaceae family).
    Trianthenol
Cat. No. Product Name / Synonyms Application Reactivity