Lienomycin
Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 12710-02-0
- Formula: C67H107NO18
- Molecular Weight:1214.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 12710-02-0
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Molecular Weight 1214.56
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Formula C67H107NO18
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SMILES
C[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](OC2C/C=C(CCC=C)/CC/C=C/[C@@H](O)[C@H](C)[C@@H](O)C(C)/C=C\C=C\C=C/C=C/C=C/CCC(O[C@H](/C=C/C[C@@H](O)/C=C/C[C@H](O)CCCN)C[C@H](O)C[C@@H](O)C[C@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC(O)CC(C2C)=O)=O)O1
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Structure Classification
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Initial Source
Actinomyces diastatochromogenes
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lienomycin Related Classifications
HY-129728 Related Classifications
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